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dc.contributor.authorZaytseva, O
dc.contributor.authorKim, N-H
dc.contributor.authorQuinn, LM
dc.date.accessioned2020-11-27T00:58:31Z
dc.date.available2020-11-27T00:58:31Z
dc.date.issued2020-10-20
dc.identifierpii: ijms21207742
dc.identifier.citationZaytseva, O., Kim, N. -H. & Quinn, L. M. (2020). MYC in Brain Development and Cancer.. Int J Mol Sci, 21 (20), pp.1-14. https://doi.org/10.3390/ijms21207742.
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/11343/252661
dc.description.abstractThe MYC family of transcriptional regulators play significant roles in animal development, including the renewal and maintenance of stem cells. Not surprisingly, given MYC's capacity to promote programs of proliferative cell growth, MYC is frequently upregulated in cancer. Although members of the MYC family are upregulated in nervous system tumours, the mechanisms of how elevated MYC promotes stem cell-driven brain cancers is unknown. If we are to determine how increased MYC might contribute to brain cancer progression, we will require a more complete understanding of MYC's roles during normal brain development. Here, we evaluate evidence for MYC family functions in neural stem cell fate and brain development, with a view to better understand mechanisms of MYC-driven neural malignancies.
dc.languageeng
dc.publisherMDPI AG
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleMYC in Brain Development and Cancer.
dc.typeJournal Article
dc.identifier.doi10.3390/ijms21207742
melbourne.affiliation.departmentAnatomy and Neuroscience
melbourne.source.titleInternational Journal of Molecular Sciences
melbourne.source.volume21
melbourne.source.issue20
melbourne.source.pages1-14
dc.rights.licenseCC BY
melbourne.elementsid1478393
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588885
melbourne.contributor.authorQuinn, Leonie
dc.identifier.eissn1422-0067
melbourne.accessrightsOpen Access


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