University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne School of Health Sciences
  • Nursing
  • Nursing - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne School of Health Sciences
  • Nursing
  • Nursing - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    The effect of 17 beta-estradiol on maternal immune activation-induced changes in prepulse inhibition and dopamine receptor and transporter binding in female rats

    Thumbnail
    Citations
    Altmetric
    Author
    Sbisa, A; Kusljic, S; Zethoven, D; van den Buuse, M; Gogos, A
    Date
    2020-09-01
    Source Title
    Schizophrenia Research
    Publisher
    ELSEVIER
    University of Melbourne Author/s
    Kusljic, Snezana; Gogos, Androniki; Sbisa, Alyssa; Sbisa, Alyssa Morgan
    Affiliation
    Nursing
    Florey Department of Neuroscience and Mental Health
    Psychiatry
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Sbisa, A., Kusljic, S., Zethoven, D., van den Buuse, M. & Gogos, A. (2020). The effect of 17 beta-estradiol on maternal immune activation-induced changes in prepulse inhibition and dopamine receptor and transporter binding in female rats. SCHIZOPHRENIA RESEARCH, 223, pp.249-257. https://doi.org/10.1016/j.schres.2020.08.015.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/252871
    DOI
    10.1016/j.schres.2020.08.015
    Abstract
    Maternal immune activation (MIA) during pregnancy is associated with an increased risk of development of schizophrenia in later life. 17β-estradiol treatment may improve schizophrenia symptoms, but little is known about its efficacy on MIA-induced psychosis-like behavioural deficits in animals. Therefore, in this study we used the poly(I:C) neurodevelopmental model of schizophrenia to examine whether MIA-induced psychosis-like behavioural and neurochemical changes can be attenuated by chronic treatment (2-6 weeks) with 17β-estradiol. Pregnant rats were treated with saline or the viral mimetic, poly(I:C), on gestational day 15 and adult female offspring were tested for changes in prepulse inhibition (PPI) and density of dopamine D1 and D2 receptors and dopamine transporters in the forebrain compared to control offspring. Poly(I:C)-treated offspring exhibited significantly disrupted PPI, an effect which was reversed by chronic treatment with 17β-estradiol. In control offspring, but not poly(I:C) offspring, PPI was significantly reduced by acute treatment with either the dopamine D1/D2 receptor agonist, apomorphine, or dopamine releaser, methamphetamine. 17β-estradiol restored the effect of apomorphine, but not methamphetamine, on PPI in poly(I:C) offspring. There was a strong trend for a dopamine D2 receptor binding density increase in the nucleus accumbens core region in poly(I:C) offspring, and this was reversed by chronic 17β-estradiol treatment. No changes were found in the nucleus accumbens shell, caudate putamen or frontal cortex or in the density of dopamine D1 receptors or transporters. These findings suggest that 17β-estradiol may improve some symptoms of schizophrenia, an effect that may be mediated by selective changes in dopamine D2 receptor density.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [45770]
    • Psychiatry - Research Publications [1103]
    • Florey Department of Neuroscience and Mental Health - Research Publications [1052]
    • Nursing - Research Publications [178]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors