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    Patient-Reported Outcomes Following Total Knee Replacement in Patients < 65 Years of Age-A Systematic Review and Meta-Analysis

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    Author
    Trieu, J; Gould, DJ; Schilling, C; Spelman, T; Dowsey, MM; Choong, PF
    Date
    2020-10-01
    Source Title
    Journal of Clinical Medicine
    Publisher
    MDPI
    University of Melbourne Author/s
    Dowsey, Michelle
    Affiliation
    Surgery (St Vincent's)
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Trieu, J., Gould, D. J., Schilling, C., Spelman, T., Dowsey, M. M. & Choong, P. F. (2020). Patient-Reported Outcomes Following Total Knee Replacement in Patients < 65 Years of Age-A Systematic Review and Meta-Analysis. JOURNAL OF CLINICAL MEDICINE, 9 (10), https://doi.org/10.3390/jcm9103150.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/252920
    DOI
    10.3390/jcm9103150
    Abstract
    An increasing number of total knee replacements (TKRs) are being performed in response to the growing burden of osteoarthritis. Patients <65 years of age represent the fastest growing group of TKR recipients and are expected to account for an increasing number of primary and revision procedures. Concerns have been raised about the outcomes that can be expected by this age demographic who are more active, physically demanding, and have longer life expectancies compared to older TKR recipients. This systematic review and meta-analysis evaluated the effectiveness of TKR for osteoarthritis in patients <65 years of age, compared to older individuals. A systematic search of Embase and Medline was conducted to identify studies which examined patient-reported outcomes measured using disease-specific and generic health-related quality of life instruments. Ten studies met our inclusion criteria and were included in this review. These studies comprised 1747 TKRs performed between 1977 and 2014. In the meta-analysis of two prospective studies (288 TKRs), patients <65 years of age were able to attain large and clinically meaningful improvements in pain, function, and quality of life. One of these studies (61 TKRs) suggested that patients <55 years of age attained a larger degree of improvement compared to older individuals. Results into the second postoperative decade were less certain, with some data suggesting a high prevalence of pain and patterns of functional decline. Further research is required to investigate longer-term outcomes following TKR for osteoarthritis in younger patients.

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