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    Point-of-Care Tests for Hepatitis B: An Overview

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    Author
    Xiao, Y; Thompson, AJ; Howell, J
    Date
    2020-10-01
    Source Title
    Cells
    Publisher
    MDPI
    University of Melbourne Author/s
    Howell, Jessica; Thompson, Alexander
    Affiliation
    Medicine and Radiology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Xiao, Y., Thompson, A. J. & Howell, J. (2020). Point-of-Care Tests for Hepatitis B: An Overview. CELLS, 9 (10), https://doi.org/10.3390/cells9102233.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/252934
    DOI
    10.3390/cells9102233
    Abstract
    Despite the heavy disease burden posed by hepatitis B, around 90% of people living with hepatitis B are not diagnosed globally. Many of the affected populations still have limited or no access to essential blood tests for hepatitis B. Compared to conventional blood tests which heavily rely on centralised laboratory facilities, point-of-care testing for hepatitis B has the potential to broaden testing access in low-resource settings and to engage hard-to-reach populations. Few hepatitis B point-of-care tests have been ratified for clinical use by international and regional regulatory bodies, and countries have been slow to adopt point-of-care testing into hepatitis B programs. This review presents currently available point-of-care tests for hepatitis B and their roles in the care cascade, reviewing evidence for testing performance, utility, acceptability, costs and cost-effectiveness when integrated into hepatitis B diagnosis and monitoring programs. We further discuss challenges and future directions in aspects of technology, implementation, and regulation when adopting point-of-care testing in hepatitis B programs.

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