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    Adsorption of Blood Components to Extracorporeal Membrane Oxygenation (ECMO) Surfaces in Humans: A Systematic Review

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    Author
    Callaghan, S; Cai, T; McCafferty, C; Van Den Helm, S; Horton, S; MacLaren, G; Monagle, P; Ignjatovic, V
    Date
    2020-10-01
    Source Title
    Journal of Clinical Medicine
    Publisher
    MDPI
    University of Melbourne Author/s
    MacLaren, Graeme; Ignjatovic, Vera; Monagle, Paul; Horton, Stephen; Mccafferty, Conor
    Affiliation
    Paediatrics (RCH)
    Metadata
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    Document Type
    Journal Article
    Citations
    Callaghan, S., Cai, T., McCafferty, C., Van Den Helm, S., Horton, S., MacLaren, G., Monagle, P. & Ignjatovic, V. (2020). Adsorption of Blood Components to Extracorporeal Membrane Oxygenation (ECMO) Surfaces in Humans: A Systematic Review. JOURNAL OF CLINICAL MEDICINE, 9 (10), https://doi.org/10.3390/jcm9103272.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/252938
    DOI
    10.3390/jcm9103272
    Abstract
    The accumulation of blood proteins and cells on extracorporeal membrane oxygenation (ECMO) circuits has been proposed as a contributing factor to the coagulopathic state of many patients. This systematic review aims to summarize and discuss the existing knowledge of blood components binding to the ECMO circuits in human patients. A systematic review was conducted using the Medline, PubMed and Embase databases following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Seven studies were included in this review. Three studies identified a leukocyte adhesion, three studies observed von Willebrand factor accumulation and four studies identified bound platelets on the surface of the circuits. Other identified components included fibrin, albumin, hemoglobin, erythrocytes, progenitor cells, fibronectin and IgG. This systematic review demonstrates the limited state of knowledge when it comes to adsorption to the ECMO circuits in humans. Most of the studies lacked insight or detail into the mechanisms of binding and the interactions between different components bound to the ECMO circuits. Further research is required to comprehensively characterize surface adsorption to ECMO circuits in humans and to define the specific mechanisms of binding, enabling improvements that increase biocompatibility between the blood-circuit interface in this important clinical setting.

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