GM-CSF: A Promising Target in Inflammation and Autoimmunity
AuthorLee, KMC; Achuthan, AA; Hamilton, JA
Source TitleIMMUNOTARGETS AND THERAPY
PublisherDOVE MEDICAL PRESS LTD
AffiliationMedicine and Radiology
Document TypeJournal Article
CitationsLee, K. M. C., Achuthan, A. A. & Hamilton, J. A. (2020). GM-CSF: A Promising Target in Inflammation and Autoimmunity. IMMUNOTARGETS AND THERAPY, 9, pp.225-240. https://doi.org/10.2147/ITT.S262566.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605919
The cytokine, granulocyte macrophage-colony stimulating factor (GM-CSF), was firstly identified as being able to induce in vitro the proliferation and differentiation of bone marrow progenitors into granulocytes and macrophages. Much preclinical data have indicated that GM-CSF has a wide range of functions across different tissues in its action on myeloid cells, and GM-CSF deletion/depletion approaches indicate its potential as an important therapeutic target in several inflammatory and autoimmune disorders, for example, rheumatoid arthritis. In this review, we discuss briefly the biology of GM-CSF, raise some current issues and questions pertaining to this biology, summarize the results from preclinical models of a range of inflammatory and autoimmune disorders and list the latest clinical trials evaluating GM-CSF blockade in such disorders.
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