University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Surgery (Austin & Northern Health)
  • Surgery (Austin & Northern Health) - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Surgery (Austin & Northern Health)
  • Surgery (Austin & Northern Health) - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Cannabinoids Inhibited Pancreatic Cancer via P-21 Activated Kinase 1 Mediated Pathway

    Thumbnail
    Download
    Published version (2.212Mb)

    Citations
    Altmetric
    Author
    Yang, Y; Nhi, H; Dumesny, C; Wang, K; He, H; Nikfarjam, M
    Date
    2020-11-01
    Source Title
    International Journal of Molecular Sciences
    Publisher
    MDPI
    University of Melbourne Author/s
    Nikfarjam, Mehrdad; He, Hong; Dumesny, Chelsea; Yang, Yang; Wang, Kai
    Affiliation
    Surgery (Austin & Northern Health)
    Surgery (RMH)
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Yang, Y., Nhi, H., Dumesny, C., Wang, K., He, H. & Nikfarjam, M. (2020). Cannabinoids Inhibited Pancreatic Cancer via P-21 Activated Kinase 1 Mediated Pathway. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21 (21), https://doi.org/10.3390/ijms21218035.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/252969
    DOI
    10.3390/ijms21218035
    Abstract
    The anti-cancer effects of cannabinoids including CBD (Cannabidiol) and THC ((-)-trans-∆9-tetrahydrocannabinol) have been reported in the case of pancreatic cancer (PC). The connection of these cannabinoids to KRas oncogenes that mutate in more than 90% of PC, and their effects on PD-L1, a key target of immune checkpoint blockade, have not been thoroughly investigated. Using cell lines and mouse models of PC, the effects of CBD and THC on cancer growth, the interaction between PC cells and a stromal cell, namely pancreatic stellate cells (PSCs), and the mechanism(s) involved were determined by cell-based assays and mouse study in vivo. CBD and THC inhibited the proliferation of PC, PSC, and PSC-stimulated PC cells. They also suppressed pancreatic tumour growth in mice. Furthermore, CBD and/or THC reduced the expression of PD-L1 by either PC or PSC cells. Knockout of p-21 activated kinase 1 (PAK1, activated by KRas) in PC and PSC cells and, in mice, dramatically decreased or blocked these inhibitory effects of CBD and/or THC. These results indicated that CBD and THC exerted their inhibitions on PC and PSC via a p-21 activated kinase 1 (PAK1)-dependent pathway, suggesting that CBD and THC suppress Kras activated pathway by targeting PAK1. The inhibition by CBD and THC of PD-L1 expression will enhance the immune checkpoint blockade of PC.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [53102]
    • Surgery (RMH) - Research Publications [347]
    • Surgery (Austin & Northern Health) - Research Publications [406]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors