University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Medical Biology
  • Medical Biology - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Medical Biology
  • Medical Biology - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Severe Impairment of TNF Post-transcriptional Regulation Leads to Embryonic Death

    Thumbnail
    Download
    Published version (6.607Mb)

    Citations
    Altmetric
    Author
    Clayer, E; Dalseno, D; Kueh, A; Lacey, D; Tsai, M; Carr, E; Wimmer, VC; Bouillet, P
    Date
    2020-11-20
    Source Title
    iScience
    Publisher
    CELL PRESS
    University of Melbourne Author/s
    Bouillet, Philippe; Wimmer, Verena; Lacey, Derek; Kueh, Andrew
    Affiliation
    Medical Biology (W.E.H.I.)
    Anatomy and Neuroscience
    Medicine and Radiology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Clayer, E., Dalseno, D., Kueh, A., Lacey, D., Tsai, M., Carr, E., Wimmer, V. C. & Bouillet, P. (2020). Severe Impairment of TNF Post-transcriptional Regulation Leads to Embryonic Death. ISCIENCE, 23 (11), https://doi.org/10.1016/j.isci.2020.101726.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/252995
    DOI
    10.1016/j.isci.2020.101726
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658709
    Abstract
    Post-transcriptional regulation mechanisms control mRNA stability or translational efficiency via ribosomes, and recent evidence indicates that it is a major determinant of the accurate levels of cytokine mRNAs. Transcriptional regulation of Tnf has been well studied and found to be important for the rapid induction of Tnf mRNA and regulation of the acute phase of inflammation, whereas study of its post-transcriptional regulation has been largely limited to the role of the AU-rich element (ARE), and to a lesser extent, to that of the constitutive decay element (CDE). We have identified another regulatory element (NRE) in the 3' UTR of Tnf and demonstrate that ARE, CDE, and NRE cooperate in vivo to efficiently downregulate Tnf expression and prevent autoimmune inflammatory diseases. We also show that excessive TNF may lead to embryonic death.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [45689]
    • Medicine and Radiology - Research Publications [2346]
    • Anatomy and Neuroscience - Research Publications [621]
    • Medical Biology - Research Publications [865]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors