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dc.contributor.authorClayer, E
dc.contributor.authorDalseno, D
dc.contributor.authorKueh, A
dc.contributor.authorLacey, D
dc.contributor.authorTsai, M
dc.contributor.authorCarr, E
dc.contributor.authorWimmer, VC
dc.contributor.authorBouillet, P
dc.date.accessioned2020-12-09T22:32:24Z
dc.date.available2020-12-09T22:32:24Z
dc.date.issued2020-11-20
dc.identifierpii: S2589-0042(20)30923-8
dc.identifier.citationClayer, E., Dalseno, D., Kueh, A., Lacey, D., Tsai, M., Carr, E., Wimmer, V. C. & Bouillet, P. (2020). Severe Impairment of TNF Post-transcriptional Regulation Leads to Embryonic Death. ISCIENCE, 23 (11), https://doi.org/10.1016/j.isci.2020.101726.
dc.identifier.issn2589-0042
dc.identifier.urihttp://hdl.handle.net/11343/252995
dc.description.abstractPost-transcriptional regulation mechanisms control mRNA stability or translational efficiency via ribosomes, and recent evidence indicates that it is a major determinant of the accurate levels of cytokine mRNAs. Transcriptional regulation of Tnf has been well studied and found to be important for the rapid induction of Tnf mRNA and regulation of the acute phase of inflammation, whereas study of its post-transcriptional regulation has been largely limited to the role of the AU-rich element (ARE), and to a lesser extent, to that of the constitutive decay element (CDE). We have identified another regulatory element (NRE) in the 3' UTR of Tnf and demonstrate that ARE, CDE, and NRE cooperate in vivo to efficiently downregulate Tnf expression and prevent autoimmune inflammatory diseases. We also show that excessive TNF may lead to embryonic death.
dc.languageEnglish
dc.publisherCELL PRESS
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleSevere Impairment of TNF Post-transcriptional Regulation Leads to Embryonic Death
dc.typeJournal Article
dc.identifier.doi10.1016/j.isci.2020.101726
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.affiliation.departmentAnatomy and Neuroscience
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleiScience
melbourne.source.volume23
melbourne.source.issue11
melbourne.source.pages101726-
melbourne.identifier.nhmrc461221
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1480178
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658709
melbourne.contributor.authorBouillet, Philippe
melbourne.contributor.authorWimmer, Verena
melbourne.contributor.authorKueh, Andrew
dc.identifier.eissn2589-0042
melbourne.identifier.fundernameidNHMRC, 461221
melbourne.accessrightsOpen Access


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