Resident Memory T Cells and Their Role within the Liver
AuthorGhilas, S; Valencia-Hernandez, A-M; Enders, MH; Heath, WR; Fernandez-Ruiz, D
Source TitleInternational Journal of Molecular Sciences
University of Melbourne Author/sHeath, William; Ghilas, Sonia; Fernandez Ruiz, Daniel; Valencia-Hernandez, Ana
AffiliationMicrobiology and Immunology
Document TypeJournal Article
CitationsGhilas, S., Valencia-Hernandez, A. -M., Enders, M. H., Heath, W. R. & Fernandez-Ruiz, D. (2020). Resident Memory T Cells and Their Role within the Liver. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21 (22), https://doi.org/10.3390/ijms21228565.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696659
Immunological memory is fundamental to maintain immunity against re-invading pathogens. It is the basis for prolonged protection induced by vaccines and can be mediated by humoral or cellular responses-the latter largely mediated by T cells. Memory T cells belong to different subsets with specialized functions and distributions within the body. They can be broadly separated into circulating memory cells, which pace the entire body through the lymphatics and blood, and tissue-resident memory T (TRM) cells, which are constrained to peripheral tissues. Retained in the tissues where they form, TRM cells provide a frontline defense against reinfection. Here, we review this population of cells with specific attention to the liver, where TRM cells have been found to protect against infections, in particular those by Plasmodium species that cause malaria.
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