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    Resident Memory T Cells and Their Role within the Liver

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    Author
    Ghilas, S; Valencia-Hernandez, A-M; Enders, MH; Heath, WR; Fernandez-Ruiz, D
    Date
    2020-11-01
    Source Title
    International Journal of Molecular Sciences
    Publisher
    MDPI
    University of Melbourne Author/s
    Heath, William; Ghilas, Sonia; Valencia Hernandez, Ana Maria
    Affiliation
    Microbiology and Immunology
    Metadata
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    Document Type
    Journal Article
    Citations
    Ghilas, S., Valencia-Hernandez, A. -M., Enders, M. H., Heath, W. R. & Fernandez-Ruiz, D. (2020). Resident Memory T Cells and Their Role within the Liver. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21 (22), https://doi.org/10.3390/ijms21228565.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/253002
    DOI
    10.3390/ijms21228565
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696659
    Abstract
    Immunological memory is fundamental to maintain immunity against re-invading pathogens. It is the basis for prolonged protection induced by vaccines and can be mediated by humoral or cellular responses-the latter largely mediated by T cells. Memory T cells belong to different subsets with specialized functions and distributions within the body. They can be broadly separated into circulating memory cells, which pace the entire body through the lymphatics and blood, and tissue-resident memory T (TRM) cells, which are constrained to peripheral tissues. Retained in the tissues where they form, TRM cells provide a frontline defense against reinfection. Here, we review this population of cells with specific attention to the liver, where TRM cells have been found to protect against infections, in particular those by Plasmodium species that cause malaria.

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