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    New Technologies for Influenza Vaccines

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    Author
    Rockman, S; Laurie, KL; Parkes, S; Wheatley, A; Barr, IG
    Date
    2020-11-01
    Source Title
    Microorganisms
    Publisher
    MDPI
    University of Melbourne Author/s
    Laurie, Karen; Wheatley, Adam; Rockman, Steven; Barr, Ian
    Affiliation
    Microbiology and Immunology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Rockman, S., Laurie, K. L., Parkes, S., Wheatley, A. & Barr, I. G. (2020). New Technologies for Influenza Vaccines. MICROORGANISMS, 8 (11), https://doi.org/10.3390/microorganisms8111745.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/253015
    DOI
    10.3390/microorganisms8111745
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694987
    Abstract
    Vaccine development has been hampered by the long lead times and the high cost required to reach the market. The 2020 pandemic, caused by a new coronavirus (SARS-CoV-2) that was first reported in late 2019, has seen unprecedented rapid activity to generate a vaccine, which belies the traditional vaccine development cycle. Critically, much of this progress has been leveraged off existing technologies, many of which had their beginnings in influenza vaccine development. This commentary outlines the most promising of the next generation of non-egg-based influenza vaccines including new manufacturing platforms, structure-based antigen design/computational biology, protein-based vaccines including recombinant technologies, nanoparticles, gene- and vector-based technologies, as well as an update on activities around a universal influenza vaccine.

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