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    Quality of life and mortality in the general population: a systematic review and meta-analysis.

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    Author
    Phyo, AZZ; Freak-Poli, R; Craig, H; Gasevic, D; Stocks, NP; Gonzalez-Chica, DA; Ryan, J
    Date
    2020-11-06
    Source Title
    BMC Public Health
    Publisher
    Springer Science and Business Media LLC
    University of Melbourne Author/s
    Ryan, Joanne
    Affiliation
    Paediatrics (RCH)
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Phyo, A. Z. Z., Freak-Poli, R., Craig, H., Gasevic, D., Stocks, N. P., Gonzalez-Chica, D. A. & Ryan, J. (2020). Quality of life and mortality in the general population: a systematic review and meta-analysis.. BMC Public Health, 20 (1), pp.1596-. https://doi.org/10.1186/s12889-020-09639-9.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/253029
    DOI
    10.1186/s12889-020-09639-9
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646076
    Abstract
    BACKGROUND: Quality of life (QoL) is multi-dimensional concept of an individual' general well-being status in relation to their value, environment, cultural and social context in which they live. This study aimed to quantitatively synthesise available evidence on the association between QoL and mortality in the general population. METHODS: An electronic search was conducted using three bibliographic databases, MEDLINE, EMBASE and PsycINFO. Inclusion criteria were studies that assessed QoL using standardized tools and examined mortality risk in a non-patient population. Qualitative data synthesis and meta-analyses using a random-effects model were performed. RESULTS: Of 4184 articles identified, 47 were eligible for inclusion, involving approximately 1,200,000 participants. Studies were highly heterogeneous in terms of QoL measures, population characteristics and data analysis. In total, 43 studies (91.5%) reported that better QoL was associated with lower mortality risk. The results of four meta-analyses indicated that higher health-related QoL (HRQoL) is associated with lower mortality risk, which was consistent for overall HRQoL (HR 0.633, 95% CI: 0.514 to 0.780), physical function (HR 0.987, 95% CI: 0.982 to 0.992), physical component score (OR 0.950, 95% CI: 0.935 to 0.965), and mental component score (OR 0.980, 95% CI: 0.969 to 0.992). CONCLUSION: These findings provide evidence that better QoL/HRQoL was associated with lower mortality risk. The utility of these measures in predicting mortality risk indicates that they should be considered further as potential screening tools in general clinical practice, beyond the traditional objective measures such as body mass index and the results of laboratory tests.

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