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    Variation by lineage in serum antibody responses to influenza B virus infections

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    Author
    Lau, YC; Perera, RAPM; Fang, VJ; Luk, LH; Chu, DKW; Wu, P; Barr, IG; Peiris, JSM; Cowling, BJ
    Date
    2020-11-09
    Source Title
    PLoS One
    Publisher
    PUBLIC LIBRARY SCIENCE
    University of Melbourne Author/s
    Barr, Ian
    Affiliation
    Microbiology and Immunology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Lau, Y. C., Perera, R. A. P. M., Fang, V. J., Luk, L. H., Chu, D. K. W., Wu, P., Barr, I. G., Peiris, J. S. M. & Cowling, B. J. (2020). Variation by lineage in serum antibody responses to influenza B virus infections. PLOS ONE, 15 (11), https://doi.org/10.1371/journal.pone.0241693.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/253047
    DOI
    10.1371/journal.pone.0241693
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652285
    Abstract
    Two lineages of influenza B virus currently co-circulate and have distinct antigenicity, termed Victoria and Yamagata after the B/Victoria/2/87 and B/Yamagata/16/88 strains, respectively. We analyzed antibody titer dynamics following PCR-confirmed influenza B virus infection in a longitudinal community-based cohort study conducted in Hong Kong from 2009-2014 to assess patterns in changes in antibody titers to B/Victoria and B/Yamagata viruses following infections with each lineage. Among 62 PCR-confirmed cases, almost half had undetectable hemagglutination inhibition (HAI) antibody titers to the lineage of infection both pre-infection and post-infection. Among those infected with influenza B/Victoria who showed an HAI titer response after infection, we found strong rises to the lineage of infection, positive but smaller cross-lineage HAI titer boosts, a small dependence of HAI titer boosts on pre-infection titers, and a shorter half-life of HAI titers in adults. Our study is limited by the low HAI sensitivity for non-ether-treated IBV antigen and the incapacity of performing other assays with higher sensitivity, as well as the mismatch between the B/Yamagata lineage circulating strain and the assay strain in one of the study seasons.

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