Variation by lineage in serum antibody responses to influenza B virus infections
AuthorLau, YC; Perera, RAPM; Fang, VJ; Luk, LH; Chu, DKW; Wu, P; Barr, IG; Peiris, JSM; Cowling, BJ
Source TitlePLoS One
PublisherPUBLIC LIBRARY SCIENCE
University of Melbourne Author/sBarr, Ian
AffiliationMicrobiology and Immunology
Document TypeJournal Article
CitationsLau, Y. C., Perera, R. A. P. M., Fang, V. J., Luk, L. H., Chu, D. K. W., Wu, P., Barr, I. G., Peiris, J. S. M. & Cowling, B. J. (2020). Variation by lineage in serum antibody responses to influenza B virus infections. PLOS ONE, 15 (11), https://doi.org/10.1371/journal.pone.0241693.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652285
Two lineages of influenza B virus currently co-circulate and have distinct antigenicity, termed Victoria and Yamagata after the B/Victoria/2/87 and B/Yamagata/16/88 strains, respectively. We analyzed antibody titer dynamics following PCR-confirmed influenza B virus infection in a longitudinal community-based cohort study conducted in Hong Kong from 2009-2014 to assess patterns in changes in antibody titers to B/Victoria and B/Yamagata viruses following infections with each lineage. Among 62 PCR-confirmed cases, almost half had undetectable hemagglutination inhibition (HAI) antibody titers to the lineage of infection both pre-infection and post-infection. Among those infected with influenza B/Victoria who showed an HAI titer response after infection, we found strong rises to the lineage of infection, positive but smaller cross-lineage HAI titer boosts, a small dependence of HAI titer boosts on pre-infection titers, and a shorter half-life of HAI titers in adults. Our study is limited by the low HAI sensitivity for non-ether-treated IBV antigen and the incapacity of performing other assays with higher sensitivity, as well as the mismatch between the B/Yamagata lineage circulating strain and the assay strain in one of the study seasons.
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