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    Non-antibiotic medication use in an Indonesian community cohort 0-18 months of age

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    Author
    At Thobari, J; Satria, CD; Ridora, Y; Watts, E; Handley, A; Standish, J; Bachtiar, NS; Buttery, JP; Soenarto, Y; Bines, JE
    Date
    2020-11-18
    Source Title
    PLoS One
    Publisher
    PUBLIC LIBRARY SCIENCE
    University of Melbourne Author/s
    Bines, Julie
    Affiliation
    Paediatrics (RCH)
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    At Thobari, J., Satria, C. D., Ridora, Y., Watts, E., Handley, A., Standish, J., Bachtiar, N. S., Buttery, J. P., Soenarto, Y. & Bines, J. E. (2020). Non-antibiotic medication use in an Indonesian community cohort 0-18 months of age. PLOS ONE, 15 (11), https://doi.org/10.1371/journal.pone.0242410.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/253050
    DOI
    10.1371/journal.pone.0242410
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673523
    Abstract
    BACKGROUND: Rational medication use for treatment is mandatory, particularly in children as they are vulnerable to possible hazards of drugs. Understanding the medication use pattern is of importance to identify the problems of drug therapy and to improve the appropriate use of medication among this population. METHODS: A post-hoc study of the RV3-BB Phase IIb trial to children aged 0-18 months which was conducted in Indonesia during January 2013 to July 2016. Any concomitant medication use and health events among 1621 trial participants during the 18 months of follow-up were documented. Information on medication use included the frequency, formulation, indication, duration of usage, number of regimens, medication types, and therapeutic classes. RESULTS: The majority of participants (N = 1333/1621; 82.2%) used at least one non-antibiotic medication for treatment during the 18-month observation period. A total of 7586 medication uses were recorded, mostly in oral formulation (90.5%). Of all illnesses recorded, 24.7% were treated with a single drug regimen of non-antibiotic medication. The most common therapeutic classes used were analgesics/antipyretics (30.1%), antihistamines for systemic use (17.4%), cough and cold preparations (13.5%), vitamins (8.6%), and antidiarrheals (6.6%). The main medication types used were paracetamol (29.9%), chlorpheniramine (16.8%), guaifenesin (8.9%), zinc (4.6%), and ambroxol (4.1%). Respiratory system disorder was the most common reason for medication use (51.9%), followed by gastrointestinal disorders (19.2%), pyrexia (16.9%), and skin disorders (7.0%). CONCLUSION: A large number of children were exposed to at least one medication during their early life, including those where evidence of efficacy and safety in a pediatric population is lacking. This supports the need for further research on pediatric drug therapy to improve the appropriate use of medication in this population.

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