Show simple item record

dc.contributor.authorMorales, DR
dc.contributor.authorConover, MM
dc.contributor.authorYou, SC
dc.contributor.authorPratt, N
dc.contributor.authorKostka, K
dc.contributor.authorDuarte-Salles, T
dc.contributor.authorFernández-Bertolín, S
dc.contributor.authorAragón, M
dc.contributor.authorDuVall, SL
dc.contributor.authorLynch, K
dc.contributor.authorFalconer, T
dc.contributor.authorvan Bochove, K
dc.contributor.authorSung, C
dc.contributor.authorMatheny, ME
dc.contributor.authorLambert, CG
dc.contributor.authorNyberg, F
dc.contributor.authorAlshammari, TM
dc.contributor.authorWilliams, AE
dc.contributor.authorPark, RW
dc.contributor.authorWeaver, J
dc.contributor.authorSena, AG
dc.contributor.authorSchuemie, MJ
dc.contributor.authorRijnbeek, PR
dc.contributor.authorWilliams, RD
dc.contributor.authorLane, JCE
dc.contributor.authorPrats-Uribe, A
dc.contributor.authorZhang, L
dc.contributor.authorAreia, C
dc.contributor.authorKrumholz, HM
dc.contributor.authorPrieto-Alhambra, D
dc.contributor.authorRyan, PB
dc.contributor.authorHripcsak, G
dc.contributor.authorSuchard, MA
dc.date.accessioned2020-12-09T22:46:07Z
dc.date.available2020-12-09T22:46:07Z
dc.date.issued2020-06-12
dc.identifier.citationMorales, D. R., Conover, M. M., You, S. C., Pratt, N., Kostka, K., Duarte-Salles, T., Fernández-Bertolín, S., Aragón, M., DuVall, S. L., Lynch, K., Falconer, T., van Bochove, K., Sung, C., Matheny, M. E., Lambert, C. G., Nyberg, F., Alshammari, T. M., Williams, A. E., Park, R. W. ,... Suchard, M. A. (2020). Renin-angiotensin system blockers and susceptibility to COVID-19: a multinational open science cohort study.. medRxiv, pp.2020.06.11.20125849-. https://doi.org/10.1101/2020.06.11.20125849.
dc.identifier.urihttp://hdl.handle.net/11343/253068
dc.description.abstractINTRODUCTION: Angiotensin converting enzyme inhibitors (ACEs) and angiotensin receptor blockers (ARBs) could influence infection risk of coronavirus disease (COVID-19). Observational studies to date lack pre-specification, transparency, rigorous ascertainment adjustment and international generalizability, with contradictory results. METHODS: Using electronic health records from Spain (SIDIAP) and the United States (Columbia University Irving Medical Center and Department of Veterans Affairs), we conducted a systematic cohort study with prevalent ACE, ARB, calcium channel blocker (CCB) and thiazide diuretic (THZ) use to determine relative risk of COVID-19 diagnosis and related hospitalization outcomes. The study addressed confounding through large-scale propensity score adjustment and negative control experiments. RESULTS: Following over 1.1 million antihypertensive users identified between November 2019 and January 2020, we observed no significant difference in relative COVID-19 diagnosis risk comparing ACE/ARB vs CCB/THZ monotherapy (hazard ratio: 0.98; 95% CI 0.84 - 1.14), nor any difference for mono/combination use (1.01; 0.90 - 1.15). ACE alone and ARB alone similarly showed no relative risk difference when compared to CCB/THZ monotherapy or mono/combination use. Directly comparing ACE vs. ARB demonstrated a moderately lower risk with ACE, non-significant for monotherapy (0.85; 0.69 - 1.05) and marginally significant for mono/combination users (0.88; 0.79 - 0.99). We observed, however, no significant difference between drug- classes for COVID-19 hospitalization or pneumonia risk across all comparisons. CONCLUSION: There is no clinically significant increased risk of COVID-19 diagnosis or hospitalization with ACE or ARB use. Users should not discontinue or change their treatment to avoid COVID-19.
dc.languageeng
dc.publisherCold Spring Harbor Laboratory
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0
dc.titleRenin-angiotensin system blockers and susceptibility to COVID-19: a multinational open science cohort study.
dc.typeJournal Article
dc.identifier.doi10.1101/2020.06.11.20125849
melbourne.affiliation.departmentMedicine Dentistry & Health Sciences
melbourne.source.titlemedRxiv
melbourne.source.pages2020.06.11.20125849-
dc.rights.licenseCC BY-NC
melbourne.elementsid1454605
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310640
melbourne.contributor.authorZhang, Lin
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record