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dc.contributor.authorMontgomery, MK
dc.contributor.authorFiveash, CE
dc.contributor.authorBraude, JP
dc.contributor.authorOsborne, B
dc.contributor.authorBrown, SHJ
dc.contributor.authorMitchell, TW
dc.contributor.authorTurner, N
dc.date.accessioned2020-12-09T22:53:13Z
dc.date.available2020-12-09T22:53:13Z
dc.date.issued2015-12-22
dc.identifierpii: srep18474
dc.identifier.citationMontgomery, M. K., Fiveash, C. E., Braude, J. P., Osborne, B., Brown, S. H. J., Mitchell, T. W. & Turner, N. (2015). Disparate metabolic response to fructose feeding between different mouse strains. SCIENTIFIC REPORTS, 5 (1), https://doi.org/10.1038/srep18474.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11343/253085
dc.description.abstractDiets enriched in fructose (FR) increase lipogenesis in the liver, leading to hepatic lipid accumulation and the development of insulin resistance. Previously, we have shown that in contrast to other mouse strains, BALB/c mice are resistant to high fat diet-induced metabolic deterioration, potentially due to a lack of ectopic lipid accumulation in the liver. In this study we have compared the metabolic response of BALB/c and C57BL/6 (BL6) mice to a fructose-enriched diet. Both strains of mice increased adiposity in response to FR-feeding, while only BL6 mice displayed elevated hepatic triglyceride (TAG) accumulation and glucose intolerance. The lack of hepatic TAG accumulation in BALB/c mice appeared to be linked to an altered balance between lipogenic and lipolytic pathways, while the protection from fructose-induced glucose intolerance in this strain was likely related to low levels of ER stress, a slight elevation in insulin levels and an altered profile of diacylglycerol species in the liver. Collectively these findings highlight the multifactorial nature of metabolic defects that develop in response to changes in the intake of specific nutrients and the divergent response of different mouse strains to dietary challenges.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleDisparate metabolic response to fructose feeding between different mouse strains
dc.typeJournal Article
dc.identifier.doi10.1038/srep18474
melbourne.affiliation.departmentPhysiology
melbourne.source.titleScientific Reports
melbourne.source.volume5
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1353374
melbourne.contributor.authorMontgomery, Magdalene
dc.identifier.eissn2045-2322
melbourne.accessrightsOpen Access


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