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dc.contributor.authorFerreira, GD
dc.contributor.authorSimões, JA
dc.contributor.authorSenaratna, C
dc.contributor.authorPati, S
dc.contributor.authorTimm, PF
dc.contributor.authorBatista, SR
dc.contributor.authorNunes, BP
dc.date.accessioned2020-12-09T22:53:39Z
dc.date.available2020-12-09T22:53:39Z
dc.date.issued2018-01
dc.identifierpii: 10.1177_2235042X18806986
dc.identifier.citationFerreira, G. D., Simões, J. A., Senaratna, C., Pati, S., Timm, P. F., Batista, S. R. & Nunes, B. P. (2018). Physiological markers and multimorbidity: A systematic review.. J Comorb, 8 (1), pp.2235042X18806986-. https://doi.org/10.1177/2235042X18806986.
dc.identifier.issn2235-042X
dc.identifier.urihttp://hdl.handle.net/11343/253087
dc.description.abstractBackground: Multimorbidity is the co-occurrence of two or more diseases in the same individual. One method to identify this condition at an early stage is the use of specific markers for various combinations of morbidities. Nonetheless, evidence related to physiological markers in multimorbidity is limited. Objective: The aim was to perform a systematic review to identify physiological markers associated with multimorbidity. Design: Articles available on PubMed, Register of Controlled Trials, Academic Search Premier, CINAHL, Scopus, SocINDEX, Web of Science, LILACS, and SciELO, from their inception to May 2018, were systematically searched and reviewed. The project was registered in PROSPERO under the number CRD42017055522. Results: The systematic search identified 922 papers. After evaluation, 18 articles were included in the full review reporting at least one physiological marker in coexisting diseases or which are strongly associated with the presence of multimorbidity in the future. Only five of these studies examined multimorbidity in general, identifying five physiological markers associated with multimorbidity, namely, dehydroepiandrosterone sulfate (DHEAS), interleukin 6 (IL-6), C-reactive protein (CRP), lipoprotein (Lp), and cystatin C (Cyst-C). Conclusions: There is a paucity of studies related to physiological markers in multimorbidity. DHEAS, IL-6, CRP, Lp, and Cyst-C could be the initial focus for further investigation of physiological markers related to multimorbidity.
dc.languageeng
dc.publisherSAGE Publications
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0
dc.titlePhysiological markers and multimorbidity: A systematic review.
dc.typeJournal Article
dc.identifier.doi10.1177/2235042X18806986
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.source.titleJournal of Comorbidity
melbourne.source.volume8
melbourne.source.issue1
melbourne.source.pages2235042X18806986-
dc.rights.licenseCC BY-NC
melbourne.elementsid1353448
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201184
melbourne.contributor.authorSenaratna, Baddewithana
dc.identifier.eissn2235-042X
melbourne.accessrightsOpen Access


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