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    Associations of Physical Behaviours and Behavioural Reallocations with Markers of Metabolic Health: A Compositional Data Analysis.

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    Author
    Biddle, GJH; Edwardson, CL; Henson, J; Davies, MJ; Khunti, K; Rowlands, AV; Yates, T
    Date
    2018-10-17
    Source Title
    International Journal of Environmental Research and Public Health
    Publisher
    MDPI AG
    University of Melbourne Author/s
    Khunti, Kamlesh
    Affiliation
    General Practice
    Metadata
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    Document Type
    Journal Article
    Citations
    Biddle, G. J. H., Edwardson, C. L., Henson, J., Davies, M. J., Khunti, K., Rowlands, A. V. & Yates, T. (2018). Associations of Physical Behaviours and Behavioural Reallocations with Markers of Metabolic Health: A Compositional Data Analysis.. Int J Environ Res Public Health, 15 (10), pp.2280-2280. https://doi.org/10.3390/ijerph15102280.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/253118
    DOI
    10.3390/ijerph15102280
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210541
    Abstract
    Standard statistical modelling has shown that the reallocation of sitting time to either standing or stepping may be beneficial for metabolic health. However, this overlooks the inherent dependency of time spent in all behaviours. The aim is to examine the associations between physical behaviours and markers of metabolic health (fasting glucose, fasting insulin, 2-h glucose, 2-h insulin, Homeostasis Model Assessment of Insulin Sensitivity (HOMA-IS), Matsuda Insulin Sensitivity Index (Matsuda-ISI) while quantifying the associations of reallocating time from one physical behaviour to another using compositional analysis. Objectively measured physical behaviour data were analysed (n = 435) using compositional analysis and compositional isotemporal substitutions to estimate the association of reallocating time from one behaviour to another in a population at high risk of type 2 diabetes mellitus (T2DM). Stepping time was associated with all markers of metabolic health relative to all other behaviours. Reallocating 30 min from sleep, sitting, or standing to stepping was associated with 5⁻6 fold lower 2-h glucose, 15⁻17 fold lower 2-h insulin, and higher insulin sensitivity (10⁻11 fold via HOMA-IS, 12⁻15 fold via Matsuda-ISI). Associations of reallocating time from any behaviour to stepping were maintained for 2-h glucose, 2-h insulin, and Matsuda-ISI after further adjusting for body mass index (BMI). Relocating time from stepping into sleep, sitting, or standing was associated with lower insulin sensitivity. Stepping time may be the most important behavioural composition when promoting improved metabolic health in adults at risk of T2DM.

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