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dc.contributor.authorToliman, PJ
dc.contributor.authorKaldor, JM
dc.contributor.authorBadman, SG
dc.contributor.authorGabuzzi, J
dc.contributor.authorSilim, S
dc.contributor.authorKumbia, A
dc.contributor.authorKombuk, B
dc.contributor.authorKombati, Z
dc.contributor.authorMunnull, G
dc.contributor.authorGuy, R
dc.contributor.authorVallely, LM
dc.contributor.authorKelly-Hanku, A
dc.contributor.authorWand, H
dc.contributor.authorRyan, C
dc.contributor.authorTan, G
dc.contributor.authorBrotherton, J
dc.contributor.authorSaville, M
dc.contributor.authorMola, GDL
dc.contributor.authorGarland, SM
dc.contributor.authorTabrizi, SN
dc.contributor.authorVallely, AJ
dc.date.accessioned2020-12-09T23:02:07Z
dc.date.available2020-12-09T23:02:07Z
dc.date.issued2018-12-01
dc.identifierpii: S2405-8521(18)30108-3
dc.identifier.citationToliman, P. J., Kaldor, J. M., Badman, S. G., Gabuzzi, J., Silim, S., Kumbia, A., Kombuk, B., Kombati, Z., Munnull, G., Guy, R., Vallely, L. M., Kelly-Hanku, A., Wand, H., Ryan, C., Tan, G., Brotherton, J., Saville, M., Mola, G. D. L., Garland, S. M. ,... Vallely, A. J. (2018). Performance of clinical screening algorithms comprising point-of-care HPV-DNA testing using self-collected vaginal specimens, and visual inspection of the cervix with acetic acid, for the detection of underlying high-grade squamous intraepithelial lesions in Papua New Guinea. PAPILLOMAVIRUS RESEARCH, 6, pp.70-76. https://doi.org/10.1016/j.pvr.2018.10.009.
dc.identifier.issn2405-8521
dc.identifier.urihttp://hdl.handle.net/11343/253123
dc.description.abstractThe performance of different clinical screening algorithms comprising point-of-care HPV-DNA testing using self-collected vaginal ('V') specimens, and visual inspection of the cervix with acetic acid (VIA) was evaluated in Papua New Guinea. Women aged 30-59 years provided V specimens that were tested at point-of-care using the Xpert HPV Test (Cepheid, Sunnyvale, CA). A clinician-collected cervical ('C') specimen was then collected for point-of-care Xpert testing, and liquid-based cytology (LBC). Following this, VIA examination was conducted, blind to HPV test results, and ablative cervical cryotherapy provided if indicated. Detection of high-grade squamous intraepithelial lesion (HSIL) by LBC was the reference standard used to evaluate clinical screening algorithms. Of 1005 women, 36 had HSIL+. Xpert HPV Test performance using V specimens (sensitivity 91.7%, specificity 87.0%, PPV 34.0%, NPV 99.3%) was superior to VIA examination alone (51.5%, 81.4%, 17.5%, 95.6% respectively) in predicting underlying HSIL+. A screening algorithm comprising V specimen HPV testing followed by VIA examination had low sensitivity (45.5%) but comparable specificity, PPV and NPV to HPV testing alone (96.3%, 45.5%, 96.3% respectively). A 'test-and-treat' screening algorithm based on point-of-care HPV testing of V specimens had superior performance compared with either VIA examination alone, or a combined screening algorithm comprising HPV testing plus VIA.
dc.languageEnglish
dc.publisherELSEVIER SCIENCE BV
dc.titlePerformance of clinical screening algorithms comprising point-of-care HPV-DNA testing using self-collected vaginal specimens, and visual inspection of the cervix with acetic acid, for the detection of underlying high-grade squamous intraepithelial lesions in Papua New Guinea
dc.typeJournal Article
dc.identifier.doi10.1016/j.pvr.2018.10.009
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.affiliation.departmentObstetrics and Gynaecology
melbourne.source.titlePapillomavirus Research
melbourne.source.volume6
melbourne.source.pages70-76
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1355562
melbourne.contributor.authorTabrizi, Sepehr
melbourne.contributor.authorBrotherton, Julia
melbourne.contributor.authorWark, Suzanne
melbourne.contributor.authorSaville, Marion
melbourne.contributor.authorNightingale, Claire
dc.identifier.eissn2405-8521
melbourne.accessrightsOpen Access


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