University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Anatomy and Neuroscience
  • Anatomy and Neuroscience - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Anatomy and Neuroscience
  • Anatomy and Neuroscience - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Resistin, an Adipokine with Non-Generalized Actions on Sympathetic Nerve Activity.

    Thumbnail
    Download
    Published version (2.317Mb)

    Citations
    Scopus
    Web of Science
    Altmetric
    13
    120
    Author
    Badoer, E; Kosari, S; Stebbing, MJ
    Date
    2015
    Source Title
    Frontiers in Physiology
    Publisher
    Frontiers Media SA
    University of Melbourne Author/s
    Stebbing, Martin
    Affiliation
    Anatomy and Neuroscience
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Badoer, E., Kosari, S. & Stebbing, M. J. (2015). Resistin, an Adipokine with Non-Generalized Actions on Sympathetic Nerve Activity.. Front Physiol, 6 (NOV), pp.321-. https://doi.org/10.3389/fphys.2015.00321.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/253139
    DOI
    10.3389/fphys.2015.00321
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639629
    Abstract
    The World Health Organization has called obesity a global epidemic. There is a strong association between body weight gain and blood pressure. A major determinant of blood pressure is the level of activity in sympathetic nerves innervating cardiovascular organs. A characteristic of obesity, in both humans and in animal models, is an increase in sympathetic nerve activity to the skeletal muscle vasculature and to the kidneys. Obesity is now recognized as a chronic, low level inflammatory condition, and pro-inflammatory cytokines are elevated including those produced by adipose tissue. The most well-known adipokine released from fat tissue is leptin. The adipokine, resistin, is also released from adipose tissue. Resistin can act in the central nervous system to influence the sympathetic nerve activity. Here, we review the effects of resistin on sympathetic nerve activity and compare them with leptin. We build an argument that resistin and leptin may have complex interactions. Firstly, they may augment each other as both are excitatory on sympathetic nerves innervating cardiovascular organs; In contrast, they could antagonize each other's actions on brown adipose tissue, a key metabolic organ. These interactions may be important in conditions in which leptin and resistin are elevated, such as in obesity.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [53102]
    • Anatomy and Neuroscience - Research Publications [805]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors