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dc.contributor.authorLampit, A
dc.contributor.authorHallock, H
dc.contributor.authorSuo, C
dc.contributor.authorNaismith, SL
dc.contributor.authorValenzuela, M
dc.date.accessioned2020-12-09T23:06:00Z
dc.date.available2020-12-09T23:06:00Z
dc.date.issued2015-03-09
dc.identifier.citationLampit, A., Hallock, H., Suo, C., Naismith, S. L. & Valenzuela, M. (2015). Cognitive training-induced short-term functional and long-term structural plastic change is related to gains in global cognition in healthy older adults: a pilot study. FRONTIERS IN AGING NEUROSCIENCE, 7 (MAR), https://doi.org/10.3389/fnagi.2015.00014.
dc.identifier.issn1663-4365
dc.identifier.urihttp://hdl.handle.net/11343/253143
dc.description.abstractComputerized cognitive training (CCT) is a safe and inexpensive intervention to enhance cognitive performance in the elderly. However, the neural underpinning of CCT-induced effects and the timecourse by which such neural changes occur are unknown. Here, we report on results from a pilot study of healthy older adults who underwent three 1-h weekly sessions of either multidomain CCT program (n = 7) or an active control intervention (n = 5) over 12 weeks. Multimodal magnetic resonance imaging (MRI) scans and cognitive assessments were performed at baseline and after 9 and 36 h of training. Voxel-based structural analysis revealed a significant Group × Time interaction in the right post-central gyrus indicating increased gray matter density in the CCT group compared to active control at both follow-ups. Across the entire sample, there were significant positive correlations between changes in the post-central gyrus and change in global cognition after 36 h of training. A post-hoc vertex-based analysis found a significant between-group difference in rate of thickness change between baseline and post-training in the left fusiform gyrus, as well as a large cluster in the right parietal lobe covering the supramarginal and post-central gyri. Resting-state functional connectivity between the posterior cingulate and the superior frontal gyrus, and between the right hippocampus and the superior temporal gyrus significantly differed between the two groups after 9 h of training and correlated with cognitive change post-training. No significant interactions were found for any of the spectroscopy and diffusion tensor imaging data. Though preliminary, our results suggest that functional change may precede structural and cognitive change, and that about one-half of the structural change occurs within the first 9 h of training. Future studies are required to determine the role of these brain changes in the mechanisms underlying CCT-induced cognitive effects.
dc.languageEnglish
dc.publisherFRONTIERS MEDIA SA
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleCognitive training-induced short-term functional and long-term structural plastic change is related to gains in global cognition in healthy older adults: a pilot study
dc.typeJournal Article
dc.identifier.doi10.3389/fnagi.2015.00014
melbourne.affiliation.departmentPsychiatry
melbourne.source.titleFrontiers in Aging Neuroscience
melbourne.source.volume7
melbourne.source.issueMAR
dc.rights.licenseCC BY
melbourne.elementsid1304901
melbourne.contributor.authorLampit, Amit
dc.identifier.eissn1663-4365
melbourne.accessrightsOpen Access


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