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    Targeting Chemokines and Chemokine Receptors in Melanoma and Other Cancers

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    Author
    Jacquelot, N; Duong, CPM; Belz, GT; Zitvogel, L
    Date
    2018-10-29
    Source Title
    Frontiers in Immunology
    Publisher
    FRONTIERS MEDIA SA
    University of Melbourne Author/s
    Belz, Gabrielle; Jacquelot, Nicolas
    Affiliation
    Medical Biology (W.E.H.I.)
    Metadata
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    Document Type
    Journal Article
    Citations
    Jacquelot, N., Duong, C. P. M., Belz, G. T. & Zitvogel, L. (2018). Targeting Chemokines and Chemokine Receptors in Melanoma and Other Cancers. FRONTIERS IN IMMUNOLOGY, 9, https://doi.org/10.3389/fimmu.2018.02480.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/253144
    DOI
    10.3389/fimmu.2018.02480
    Abstract
    The tumor microenvironment is highly heterogeneous. It is composed of a diverse array of immune cells that are recruited continuously into lesions. They are guided into the tumor through interactions between chemokines and their receptors. A variety of chemokine receptors are expressed on the surface of both tumor and immune cells rendering them sensitive to multiple stimuli that can subsequently influence their migration and function. These features significantly impact tumor fate and are critical in melanoma control and progression. Indeed, particular chemokine receptors expressed on tumor and immune cells are strongly associated with patient prognosis. Thus, potential targeting of chemokine receptors is highly attractive as a means to quench or eliminate unconstrained tumor cell growth.

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