Dietary patterns and β-amyloid deposition in aging Australian women.
AuthorHill, E; Clifton, P; Goodwill, AM; Dennerstein, L; Campbell, S; Szoeke, C
Source TitleAlzheimer's and Dementia: Translational Research and Clinical Interventions
University of Melbourne Author/sSzoeke, Cassandra; Dennerstein, Lorraine; Campbell, Stephen; Goodwill, Alicia
AffiliationMedicine and Radiology
Document TypeJournal Article
CitationsHill, E., Clifton, P., Goodwill, A. M., Dennerstein, L., Campbell, S. & Szoeke, C. (2018). Dietary patterns and β-amyloid deposition in aging Australian women.. Alzheimers Dement (N Y), 4 (1), pp.535-541. https://doi.org/10.1016/j.trci.2018.09.007.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205110
Introduction: Evidence indicates that associations between diet and Alzheimer's disease may occur through biomarker pathways such as amyloid-β (Aβ); however, few studies have investigated dietary/Aβ relationships, and no study has investigated this relationship in women. Methods: Dietary patterns were extrapolated for 115 participants from the Women's Health Aging Project. Aβ deposition was measured via in vivo F-18 florbetaben positron emission tomography scanning. Results: Participants were, on average, aged 70 years (±2.63 SD), had 13 years of education (±3.57 SD), a BMI of 28 kg/m2 (±5.46 SD), and a daily energy intake of 5161 kJ (±1679.03 SD). Four dietary patterns were identified: high fat, Mediterranean, junk food, and low fat. Adherence to the junk food diet was a significant predictor of Aβ deposition (β = .10, P = .03). Discussion: This study highlights the potential of diet to influence neurodegenerative disease and as a potential modifiable lifestyle risk factor for Alzheimer's disease.
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