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dc.contributor.authorRahimi, K
dc.contributor.authorMohseni, H
dc.contributor.authorKiran, A
dc.contributor.authorTran, J
dc.contributor.authorNazarzadeh, M
dc.contributor.authorRahimian, F
dc.contributor.authorWoodward, M
dc.contributor.authorDwyer, T
dc.contributor.authorMacMahon, S
dc.contributor.authorOtto, CM
dc.date.accessioned2020-12-09T23:13:53Z
dc.date.available2020-12-09T23:13:53Z
dc.date.issued2018-10-14
dc.identifierpii: 5094940
dc.identifier.citationRahimi, K., Mohseni, H., Kiran, A., Tran, J., Nazarzadeh, M., Rahimian, F., Woodward, M., Dwyer, T., MacMahon, S. & Otto, C. M. (2018). Elevated blood pressure and risk of aortic valve disease: a cohort analysis of 5.4 million UK adults.. Eur Heart J, 39 (39), pp.3596-3603. https://doi.org/10.1093/eurheartj/ehy486.
dc.identifier.issn0195-668X
dc.identifier.urihttp://hdl.handle.net/11343/253173
dc.description.abstractAims: To test two related hypotheses that elevated blood pressure (BP) is a risk factor for aortic valve stenosis (AS) or regurgitation (AR). Methods and results: In this cohort study of 5.4 million UK patients with no known cardiovascular disease or aortic valve disease at baseline, we investigated the relationship between BP and risk of incident AS and AR using multivariable-adjusted Cox regression models. Over a median follow-up of 9.2 years, 20 680 patients (0.38%) were diagnosed with AS and 6440 (0.12%) patients with AR. Systolic BP (SBP) was continuously related to the risk of AS and AR with no evidence of a nadir down to 115 mmHg. Each 20 mmHg increment in SBP was associated with a 41% higher risk of AS (hazard ratio 1.41, 95% confidence interval 1.38-1.45) and a 38% higher risk of AR (1.38, 1.31-1.45). Associations were stronger in younger patients but with no strong evidence for interaction by gender or body mass index. Each 10 mmHg increment in diastolic BP was associated with a 24% higher risk of AS (1.24, 1.19-1.29) but not AR (1.04, 0.97-1.11). Each 15 mmHg increment in pulse pressure was associated with a 46% greater risk of AS (1.46, 1.42-1.50) and a 53% higher risk of AR (1.53, 1.45-1.62). Conclusion: Long-term exposure to elevated BP across its whole spectrum was associated with increased risk of AS and AR. The possible causal nature of the observed associations warrants further investigation.
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.titleElevated blood pressure and risk of aortic valve disease: a cohort analysis of 5.4 million UK adults.
dc.typeJournal Article
dc.identifier.doi10.1093/eurheartj/ehy486
melbourne.affiliation.departmentPaediatrics (RCH)
melbourne.source.titleEuropean Heart Journal
melbourne.source.volume39
melbourne.source.issue39
melbourne.source.pages3596-3603
dc.rights.licenseCC BY
melbourne.elementsid1355120
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186276
melbourne.contributor.authorDwyer, Terence
dc.identifier.eissn1522-9645
melbourne.accessrightsOpen Access


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