pSTM6-275, a Conjugative IncHI2 Plasmid of Salmonella enterica That Confers Antibiotic and Heavy-Metal Resistance under Changing Physiological Conditions

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    Author
    Billman-Jacobe, H; Liu, Y; Haites, R; Weaver, T; Robinson, L; Marenda, M; Dyall-Smith, M
    Date
    2018-05-01
    Source Title
    Antimicrobial Agents and Chemotherapy
    Publisher
    AMER SOC MICROBIOLOGY
    University of Melbourne Author/s
    Billman-Jacobe, Helen; Marenda, Marc; Liu, Yuhong; Haites, Ruth
    Affiliation
    Veterinary Biosciences
    Metadata
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    Document Type
    Journal Article
    Citations
    Billman-Jacobe, H., Liu, Y., Haites, R., Weaver, T., Robinson, L., Marenda, M. & Dyall-Smith, M. (2018). pSTM6-275, a Conjugative IncHI2 Plasmid of Salmonella enterica That Confers Antibiotic and Heavy-Metal Resistance under Changing Physiological Conditions. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 62 (5), https://doi.org/10.1128/AAC.02357-17.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/253202
    DOI
    10.1128/AAC.02357-17
    NHMRC Grant code
    NHMRC/1079625
    Abstract
    Detailed annotation of an IncHI2 plasmid, pSTM6-275, from Salmonella enterica serotype 1,4,5,12:i:- strain TW-Stm6 revealed a composite structure, including antimicrobial resistance genes on mobile genetic elements. The plasmid was thermosensitive for transfer to Escherichia coli and conferred reduced susceptibility to antibiotics, copper sulfate, and silver nitrate. Metal ion susceptibility was dependent on physiological conditions, giving an insight into the environments where this trait might confer a fitness advantage.

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