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    Joint genome-wide profiling of miRNA and mRNA expression in Alzheimer's disease cortex reveals altered miRNA regulation.

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    Author
    Nunez-Iglesias, J; Liu, C-C; Morgan, TE; Finch, CE; Zhou, XJ
    Date
    2010-02-01
    Source Title
    PLoS One
    Publisher
    Public Library of Science (PLoS)
    University of Melbourne Author/s
    Nunez-Iglesias, Juan
    Affiliation
    Medicine Dentistry & Health Sciences
    Metadata
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    Document Type
    Journal Article
    Citations
    Nunez-Iglesias, J., Liu, C. -C., Morgan, T. E., Finch, C. E. & Zhou, X. J. (2010). Joint genome-wide profiling of miRNA and mRNA expression in Alzheimer's disease cortex reveals altered miRNA regulation.. PLoS One, 5 (2), pp.e8898-. https://doi.org/10.1371/journal.pone.0008898.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/253216
    DOI
    10.1371/journal.pone.0008898
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813862
    Abstract
    Although microRNAs are being extensively studied for their involvement in cancer and development, little is known about their roles in Alzheimer's disease (AD). In this study, we used microarrays for the first joint profiling and analysis of miRNAs and mRNAs expression in brain cortex from AD and age-matched control subjects. These data provided the unique opportunity to study the relationship between miRNA and mRNA expression in normal and AD brains. Using a non-parametric analysis, we showed that the levels of many miRNAs can be either positively or negatively correlated with those of their target mRNAs. Comparative analysis with independent cancer datasets showed that such miRNA-mRNA expression correlations are not static, but rather context-dependent. Subsequently, we identified a large set of miRNA-mRNA associations that are changed in AD versus control, highlighting AD-specific changes in the miRNA regulatory system. Our results demonstrate a robust relationship between the levels of miRNAs and those of their targets in the brain. This has implications in the study of the molecular pathology of AD, as well as miRNA biology in general.

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