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    PPAR alpha-independent actions of omega-3 PUFAs contribute to their beneficial effects on adiposity and glucose homeostasis

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    Author
    Liu, M; Montgomery, MK; Fiveash, CE; Osborne, B; Cooney, GJ; Bell-Anderson, K; Turner, N
    Date
    2014-07-02
    Source Title
    Scientific Reports
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    Montgomery, Magdalene
    Affiliation
    Physiology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Liu, M., Montgomery, M. K., Fiveash, C. E., Osborne, B., Cooney, G. J., Bell-Anderson, K. & Turner, N. (2014). PPAR alpha-independent actions of omega-3 PUFAs contribute to their beneficial effects on adiposity and glucose homeostasis. SCIENTIFIC REPORTS, 4 (1), https://doi.org/10.1038/srep05538.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/253228
    DOI
    10.1038/srep05538
    Abstract
    Excess dietary lipid generally leads to fat deposition and impaired glucose homeostasis, but consumption of fish oil (FO) alleviates many of these detrimental effects. The beneficial effects of FO are thought to be mediated largely via activation of the nuclear receptor peroxisomal-proliferator-activated receptor α (PPARα) by omega-3 polyunsaturated fatty acids and the resulting upregulation of lipid catabolism. However, pharmacological and genetic PPARα manipulations have yielded variable results. We have compared the metabolic effects of FO supplementation and the synthetic PPARα agonist Wy-14,643 (WY) in mice fed a lard-based high-fat diet. In contrast to FO, WY treatment resulted in little protection against diet-induced obesity and glucose intolerance, despite upregulating many lipid metabolic pathways. These differences were likely due to differential effects on hepatic lipid synthesis, with FO decreasing and WY amplifying hepatic lipid accumulation. Our results highlight that the beneficial metabolic effects of FO are likely mediated through multiple independent pathways.

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