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dc.contributor.authorLiu, M
dc.contributor.authorMontgomery, MK
dc.contributor.authorFiveash, CE
dc.contributor.authorOsborne, B
dc.contributor.authorCooney, GJ
dc.contributor.authorBell-Anderson, K
dc.contributor.authorTurner, N
dc.date.accessioned2020-12-09T23:27:15Z
dc.date.available2020-12-09T23:27:15Z
dc.date.issued2014-07-02
dc.identifierpii: srep05538
dc.identifier.citationLiu, M., Montgomery, M. K., Fiveash, C. E., Osborne, B., Cooney, G. J., Bell-Anderson, K. & Turner, N. (2014). PPAR alpha-independent actions of omega-3 PUFAs contribute to their beneficial effects on adiposity and glucose homeostasis. SCIENTIFIC REPORTS, 4 (1), https://doi.org/10.1038/srep05538.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11343/253228
dc.description.abstractExcess dietary lipid generally leads to fat deposition and impaired glucose homeostasis, but consumption of fish oil (FO) alleviates many of these detrimental effects. The beneficial effects of FO are thought to be mediated largely via activation of the nuclear receptor peroxisomal-proliferator-activated receptor α (PPARα) by omega-3 polyunsaturated fatty acids and the resulting upregulation of lipid catabolism. However, pharmacological and genetic PPARα manipulations have yielded variable results. We have compared the metabolic effects of FO supplementation and the synthetic PPARα agonist Wy-14,643 (WY) in mice fed a lard-based high-fat diet. In contrast to FO, WY treatment resulted in little protection against diet-induced obesity and glucose intolerance, despite upregulating many lipid metabolic pathways. These differences were likely due to differential effects on hepatic lipid synthesis, with FO decreasing and WY amplifying hepatic lipid accumulation. Our results highlight that the beneficial metabolic effects of FO are likely mediated through multiple independent pathways.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titlePPAR alpha-independent actions of omega-3 PUFAs contribute to their beneficial effects on adiposity and glucose homeostasis
dc.typeJournal Article
dc.identifier.doi10.1038/srep05538
melbourne.affiliation.departmentPhysiology
melbourne.source.titleScientific Reports
melbourne.source.volume4
melbourne.source.issue1
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1353377
melbourne.contributor.authorMontgomery, Magdalene
dc.identifier.eissn2045-2322
melbourne.accessrightsOpen Access


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