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dc.contributor.authorZhuang, L
dc.contributor.authorLawlor, KT
dc.contributor.authorSchlueter, H
dc.contributor.authorPieterse, Z
dc.contributor.authorYu, Y
dc.contributor.authorKaur, P
dc.date.accessioned2020-12-09T23:32:21Z
dc.date.available2020-12-09T23:32:21Z
dc.date.issued2018-08-01
dc.identifierpii: LSA-2017-00009
dc.identifier.citationZhuang, L., Lawlor, K. T., Schlueter, H., Pieterse, Z., Yu, Y. & Kaur, P. (2018). Pericytes promote skin regeneration by inducing epidermal cell polarity and planar cell divisions. LIFE SCIENCE ALLIANCE, 1 (4), https://doi.org/10.26508/lsa.201700009.
dc.identifier.issn2575-1077
dc.identifier.urihttp://hdl.handle.net/11343/253252
dc.description.abstractThe cellular and molecular microenvironment of epithelial stem/progenitor cells is critical for their long-term self-renewal. We demonstrate that mesenchymal stem cell-like dermal microvascular pericytes are a critical element of the skin's microenvironment influencing human skin regeneration using organotypic models. Specifically, pericytes were capable of promoting homeostatic skin tissue renewal by conferring more planar cell divisions generating two basal cells within the proliferative compartment of the human epidermis, while ensuring complete maturation of the tissue both spatially and temporally. Moreover, we provide evidence supporting the notion that BMP-2, a secreted protein preferentially expressed by pericytes in human skin, confers cell polarity and planar divisions on epidermal cells in organotypic cultures. Our data suggest that human skin regeneration is regulated by highly conserved mechanisms at play in other rapidly renewing tissues such as the bone marrow and in lower organisms such as Drosophila. Our work also provides the means to significantly improve ex vivo skin tissue regeneration for autologous transplantation.
dc.languageEnglish
dc.publisherLIFE SCIENCE ALLIANCE LLC
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titlePericytes promote skin regeneration by inducing epidermal cell polarity and planar cell divisions
dc.typeJournal Article
dc.identifier.doi10.26508/lsa.201700009
melbourne.affiliation.departmentAnatomy and Neuroscience
melbourne.affiliation.departmentPaediatrics (RCH)
melbourne.source.titleLife Science Alliance
melbourne.source.volume1
melbourne.source.issue4
melbourne.identifier.nhmrc1043453
dc.rights.licenseCC BY
melbourne.elementsid1357586
melbourne.contributor.authorKaur, Pritinder
melbourne.contributor.authorLawlor, Kynan
dc.identifier.eissn2575-1077
melbourne.identifier.fundernameidNHMRC, 1043453
melbourne.accessrightsOpen Access


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