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    A novel group A rotavirus associated with acute illness and hepatic necrosis in pigeons (Columba livia), in Australia

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    Author
    McCowan, C; Crameri, S; Kocak, A; Shan, S; Fegan, M; Forshaw, D; Rubbenstroth, D; Chen, H; Holmes, C; Harper, J; ...
    Date
    2018-09-11
    Source Title
    PLoS One
    Publisher
    PUBLIC LIBRARY SCIENCE
    University of Melbourne Author/s
    Bergfeld, Jemma
    Affiliation
    Veterinary Biosciences
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    McCowan, C., Crameri, S., Kocak, A., Shan, S., Fegan, M., Forshaw, D., Rubbenstroth, D., Chen, H., Holmes, C., Harper, J., Dearnley, M., Batovska, J., Bergfeld, J., Walker, C. & Wang, J. (2018). A novel group A rotavirus associated with acute illness and hepatic necrosis in pigeons (Columba livia), in Australia. PLOS ONE, 13 (9), https://doi.org/10.1371/journal.pone.0203853.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/253255
    DOI
    10.1371/journal.pone.0203853
    Abstract
    Cases of vomiting and diarrhoea were reported in racing pigeons in Western Australia in May, 2016. Morbidity and mortality rates were high. Similar clinical disease was seen in Victoria in December and by early 2017 had been reported in all states except the Northern Territory, in different classes of domestic pigeon-racing, fancy and meat bird-and in a flock of feral pigeons. Autopsy findings were frequently unremarkable; histological examination demonstrated significant hepatic necrosis as the major and consistent lesion, often with minimal inflammatory infiltration. Negative contrast tissue suspension and thin section transmission electron microscopy of liver demonstrated virus particles consistent with a member of the Reoviridae. Inoculation of trypsin-treated Vero, MDBK and MA-104 cell lines resulted in cytopathic changes at two days after infection. Next generation sequencing was undertaken using fresh liver samples and a previously undescribed group A rotavirus (genotype G18P[17]) of avian origin was identified and the virus was isolated in several cell lines. A q-RT-PCR assay was developed and used to screen a wider range of samples, including recovered birds. Episodes of disease have continued to occur and to reoccur in previously recovered lofts, with variable virulence reported. This is the first report of a rotavirus associated with hepatic necrosis in any avian species.

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