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dc.contributor.authorWang, Y
dc.contributor.authorXu, X
dc.contributor.authorMaglic, D
dc.contributor.authorDill, MT
dc.contributor.authorMojumdar, K
dc.contributor.authorNg, PK-S
dc.contributor.authorJeong, KJ
dc.contributor.authorTsang, YH
dc.contributor.authorMoreno, D
dc.contributor.authorBhavana, VH
dc.contributor.authorPeng, X
dc.contributor.authorGe, Z
dc.contributor.authorChen, H
dc.contributor.authorLi, J
dc.contributor.authorChen, Z
dc.contributor.authorZhang, H
dc.contributor.authorHan, L
dc.contributor.authorDu, D
dc.contributor.authorCreighton, CJ
dc.contributor.authorMills, GB
dc.contributor.authorCamargo, F
dc.contributor.authorLiang, H
dc.date.accessioned2020-12-09T23:39:47Z
dc.date.available2020-12-09T23:39:47Z
dc.date.issued2018-10-30
dc.identifierpii: S2211-1247(18)31564-X
dc.identifier.citationWang, Y., Xu, X., Maglic, D., Dill, M. T., Mojumdar, K., Ng, P. K. -S., Jeong, K. J., Tsang, Y. H., Moreno, D., Bhavana, V. H., Peng, X., Ge, Z., Chen, H., Li, J., Chen, Z., Zhang, H., Han, L., Du, D., Creighton, C. J. ,... Liang, H. (2018). Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer. CELL REPORTS, 25 (5), pp.1304-+. https://doi.org/10.1016/j.celrep.2018.10.001.
dc.identifier.issn2211-1247
dc.identifier.urihttp://hdl.handle.net/11343/253291
dc.description.abstractHippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehensive molecular characterization of 19 Hippo core genes in 9,125 tumor samples across 33 cancer types using multidimensional "omic" data from The Cancer Genome Atlas. We identify somatic drivers among Hippo genes and the related microRNA (miRNA) regulators, and using functional genomic approaches, we experimentally characterize YAP and TAZ mutation effects and miR-590 and miR-200a regulation for TAZ. Hippo pathway activity is best characterized by a YAP/TAZ transcriptional target signature of 22 genes, which shows robust prognostic power across cancer types. Our elastic-net integrated modeling further reveals cancer-type-specific pathway regulators and associated cancer drivers. Our results highlight the importance of Hippo signaling in squamous cell cancers, characterized by frequent amplification of YAP/TAZ, high expression heterogeneity, and significant prognostic patterns. This study represents a systems-biology approach to characterizing key cancer signaling pathways in the post-genomic era.
dc.languageEnglish
dc.publisherCELL PRESS
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleComprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer
dc.typeJournal Article
dc.identifier.doi10.1016/j.celrep.2018.10.001
melbourne.affiliation.departmentSir Peter MacCallum Department of Oncology
melbourne.affiliation.departmentSurgery (RMH)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleCell Reports
melbourne.source.volume25
melbourne.source.issue5
melbourne.source.pages1304-+
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1354857
melbourne.contributor.authorBoussioutas, Alex
melbourne.contributor.authorCorcoran, Niall
melbourne.contributor.authorHovens, Christopher
melbourne.contributor.authorCostello, Anthony
dc.identifier.eissn2211-1247
melbourne.accessrightsOpen Access


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