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dc.contributor.authorThery, C
dc.contributor.authorWitwer, KW
dc.contributor.authorAikawa, E
dc.contributor.authorJose Alcaraz, M
dc.contributor.authorAnderson, JD
dc.contributor.authorAndriantsitohaina, R
dc.contributor.authorAntoniou, A
dc.contributor.authorArab, T
dc.contributor.authorArcher, F
dc.contributor.authorAtkin-Smith, GK
dc.contributor.authorAyre, DC
dc.contributor.authorBach, J-M
dc.contributor.authorBachurski, D
dc.contributor.authorBaharvand, H
dc.contributor.authorBalaj, L
dc.contributor.authorBaldacchino, S
dc.contributor.authorBauer, NN
dc.contributor.authorBaxter, AA
dc.contributor.authorBebawy, M
dc.contributor.authorBeckham, C
dc.contributor.authorZavec, AB
dc.contributor.authorBenmoussa, A
dc.contributor.authorBerardi, AC
dc.contributor.authorBergese, P
dc.contributor.authorBielska, E
dc.contributor.authorBlenkiron, C
dc.contributor.authorBobis-Wozowicz, S
dc.contributor.authorBoilard, E
dc.contributor.authorBoireau, W
dc.contributor.authorBongiovanni, A
dc.contributor.authorBorras, FE
dc.contributor.authorBosch, S
dc.contributor.authorBoulanger, CM
dc.contributor.authorBreakefield, X
dc.contributor.authorBreglio, AM
dc.contributor.authorBrennan, MA
dc.contributor.authorBrigstock, DR
dc.contributor.authorBrisson, A
dc.contributor.authorBroekman, MLD
dc.contributor.authorBromberg, JF
dc.contributor.authorBryl-Gorecka, P
dc.contributor.authorBuch, S
dc.contributor.authorBuck, AH
dc.contributor.authorBurger, D
dc.contributor.authorBusatto, S
dc.contributor.authorBuschmann, D
dc.contributor.authorBussolati, B
dc.contributor.authorBuzas, E
dc.contributor.authorByrd, JB
dc.contributor.authorCamussi, G
dc.contributor.authorCarter, DRF
dc.contributor.authorCaruso, S
dc.contributor.authorChamley, LW
dc.contributor.authorChang, Y-T
dc.contributor.authorChen, C
dc.contributor.authorChen, S
dc.contributor.authorCheng, L
dc.contributor.authorChin, AR
dc.contributor.authorClayton, A
dc.contributor.authorClerici, SP
dc.contributor.authorCocks, A
dc.contributor.authorCocucci, E
dc.contributor.authorCoffey, RJ
dc.contributor.authorCordeiro-da-Silva, A
dc.contributor.authorCouch, Y
dc.contributor.authorCoumans, FAW
dc.contributor.authorCoyle, B
dc.contributor.authorCrescitelli, R
dc.contributor.authorCriado, MF
dc.contributor.authorD'Souza-Schorey, C
dc.contributor.authorDas, S
dc.contributor.authorChaudhuri, AD
dc.contributor.authorde Candia, P
dc.contributor.authorDe Santana Junior, EF
dc.contributor.authorDe Wever, O
dc.contributor.authordel Portillo, HA
dc.contributor.authorDemaret, T
dc.contributor.authorDeville, S
dc.contributor.authorDevitt, A
dc.contributor.authorDhondt, B
dc.contributor.authorDi Vizio, D
dc.contributor.authorDieterich, LC
dc.contributor.authorDolo, V
dc.contributor.authorDominguez Rubio, AP
dc.contributor.authorDominici, M
dc.contributor.authorDourado, MR
dc.contributor.authorDriedonks, TAP
dc.contributor.authorDuarte, F
dc.contributor.authorDuncan, HM
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dc.contributor.authorFatima, F
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dc.contributor.authorForsonits, A
dc.contributor.authorFrelet-Barrand, A
dc.contributor.authorFricke, F
dc.contributor.authorFuhrmann, G
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dc.contributor.authorGiebel, B
dc.contributor.authorGilbert, C
dc.contributor.authorGimona, M
dc.contributor.authorGiusti, I
dc.contributor.authorGoberdhan, DC
dc.contributor.authorGoergens, A
dc.contributor.authorGorski, SM
dc.contributor.authorGreening, DW
dc.contributor.authorGross, JC
dc.contributor.authorGualerzi, A
dc.contributor.authorGupta, GN
dc.contributor.authorGustafson, D
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dc.contributor.authorHaraszti, RA
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dc.contributor.authorHegyesi, H
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dc.contributor.authorHill, AF
dc.contributor.authorHochberg, FH
dc.contributor.authorHoffmann, KF
dc.contributor.authorHolder, B
dc.contributor.authorHolthofer, H
dc.contributor.authorHosseinkhani, B
dc.contributor.authorHu, G
dc.contributor.authorHuang, Y
dc.contributor.authorHuber, V
dc.contributor.authorHunt, S
dc.contributor.authorIbrahim, AG-E
dc.contributor.authorIkezu, T
dc.contributor.authorInal, JM
dc.contributor.authorIsin, M
dc.contributor.authorIvanova, A
dc.contributor.authorJackson, HK
dc.contributor.authorJacobsen, S
dc.contributor.authorJay, SM
dc.contributor.authorJayachandran, M
dc.contributor.authorJenster, G
dc.contributor.authorJiang, L
dc.contributor.authorJohnson, SM
dc.contributor.authorJones, JC
dc.contributor.authorJong, A
dc.contributor.authorJovanovic-Talisman, T
dc.contributor.authorJung, S
dc.contributor.authorKalluri, R
dc.contributor.authorKano, S-I
dc.contributor.authorKaur, S
dc.contributor.authorKawamura, Y
dc.contributor.authorKeller, ET
dc.contributor.authorKhamari, D
dc.contributor.authorKhomyakova, E
dc.contributor.authorKhvorova, A
dc.contributor.authorKierulf, P
dc.contributor.authorKim, KP
dc.contributor.authorKislinger, T
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dc.contributor.authorKlinke, DJ
dc.contributor.authorKornek, M
dc.contributor.authorKosanovic, MM
dc.contributor.authorKovacs, AF
dc.contributor.authorKraemer-Albers, E-M
dc.contributor.authorKrasemann, S
dc.contributor.authorKrause, M
dc.contributor.authorKurochkin, I
dc.contributor.authorKusuma, GD
dc.contributor.authorKuypers, S
dc.contributor.authorLaitinen, S
dc.contributor.authorLangevin, SM
dc.contributor.authorLanguino, LR
dc.contributor.authorLannigan, J
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dc.contributor.authorLazaro-Ibanez, E
dc.contributor.authorLe Lay, S
dc.contributor.authorLee, M-S
dc.contributor.authorLee, YXF
dc.contributor.authorLemos, DS
dc.contributor.authorLenassi, M
dc.contributor.authorLeszczynska, A
dc.contributor.authorLi, ITS
dc.contributor.authorLiao, K
dc.contributor.authorLibregts, SF
dc.contributor.authorLigeti, E
dc.contributor.authorLim, R
dc.contributor.authorLim, SK
dc.contributor.authorLine, A
dc.contributor.authorLinnemannstoens, K
dc.contributor.authorLlorente, A
dc.contributor.authorLombard, CA
dc.contributor.authorLorenowicz, MJ
dc.contributor.authorLorincz, AM
dc.contributor.authorLotvall, J
dc.contributor.authorLovett, J
dc.contributor.authorLowry, MC
dc.contributor.authorLoyer, X
dc.contributor.authorLu, Q
dc.contributor.authorLukomska, B
dc.contributor.authorLunavat, TR
dc.contributor.authorMaas, SLN
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dc.contributor.authorMariscal, J
dc.contributor.authorMartens-Uzunova, ES
dc.contributor.authorMartin-Jaular, L
dc.contributor.authorMartinez, MC
dc.contributor.authorMartins, VR
dc.contributor.authorMathieu, M
dc.contributor.authorMathivanan, S
dc.contributor.authorMaugeri, M
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dc.contributor.authorMinciacchi, VR
dc.contributor.authorMoller, A
dc.contributor.authorJorgensen, MM
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dc.contributor.authorMorhayim, J
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dc.contributor.authorNazarenko, I
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dc.contributor.authorNeri, C
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dc.contributor.authorPulliam, L
dc.contributor.authorQuesenberry, P
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dc.contributor.authorRegev-Rudzki, N
dc.contributor.authorRicklefs, FL
dc.contributor.authorRobbins, PD
dc.contributor.authorRoberts, DD
dc.contributor.authorRodrigues, SC
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dc.contributor.authorSanchez, C
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dc.contributor.authorHelena Vasconcelos, M
dc.contributor.authorVechetti, IJ
dc.contributor.authorVeit, TD
dc.contributor.authorVella, LJ
dc.contributor.authorVelot, E
dc.contributor.authorVerweij, FJ
dc.contributor.authorVestad, B
dc.contributor.authorVinas, JL
dc.contributor.authorVisnovitz, T
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dc.contributor.authorWiener, Z
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dc.contributor.authorWolfram, J
dc.contributor.authorXagorari, A
dc.contributor.authorXander, P
dc.contributor.authorXu, J
dc.contributor.authorYan, X
dc.contributor.authorYanez-Mo, M
dc.contributor.authorYin, H
dc.contributor.authorYuana, Y
dc.contributor.authorZappulli, V
dc.contributor.authorZarubova, J
dc.contributor.authorZekas, V
dc.contributor.authorZhang, J-Y
dc.contributor.authorZhao, Z
dc.contributor.authorZheng, L
dc.contributor.authorZheutlin, AR
dc.contributor.authorZickler, AM
dc.contributor.authorZimmermann, P
dc.contributor.authorZivkovic, AM
dc.contributor.authorZocco, D
dc.contributor.authorZuba-Surma, EK
dc.date.accessioned2020-12-09T23:41:41Z
dc.date.available2020-12-09T23:41:41Z
dc.date.issued2018-11-23
dc.identifierpii: 1535750
dc.identifier.citationThery, C., Witwer, K. W., Aikawa, E., Jose Alcaraz, M., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin-Smith, G. K., Ayre, D. C., Bach, J. -M., Bachurski, D., Baharvand, H., Balaj, L., Baldacchino, S., Bauer, N. N., Baxter, A. A., Bebawy, M. ,... Zuba-Surma, E. K. (2018). Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. JOURNAL OF EXTRACELLULAR VESICLES, 7 (1), https://doi.org/10.1080/20013078.2018.1535750.
dc.identifier.issn2001-3078
dc.identifier.urihttp://hdl.handle.net/11343/253299
dc.description.abstractThe last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines for the field in 2014. We now update these "MISEV2014" guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.
dc.languageEnglish
dc.publisherWILEY
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0
dc.titleMinimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
dc.typeJournal Article
dc.identifier.doi10.1080/20013078.2018.1535750
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.source.titleJournal of Extracellular Vesicles
melbourne.source.volume7
melbourne.source.issue1
dc.rights.licenseCC BY-NC
melbourne.elementsid1359192
melbourne.contributor.authorVella, Laura
dc.identifier.eissn2001-3078
melbourne.accessrightsOpen Access


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