Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307
AuthorWyres, KL; Hawkey, J; Hetland, MAK; Fostervold, A; Wick, RR; Judd, LM; Hamidian, M; Howden, BP; Lohr, IH; Holt, KE
Source TitleJournal of Antimicrobial Chemotherapy
PublisherOXFORD UNIV PRESS
University of Melbourne Author/sJudd, Louise; Wick, Ryan; Howden, Benjamin; Holt, Kathryn; Wyres, Kelly; Hawkey, Jane
AffiliationBiochemistry and Molecular Biology
Microbiology and Immunology
Document TypeJournal Article
CitationsWyres, K. L., Hawkey, J., Hetland, M. A. K., Fostervold, A., Wick, R. R., Judd, L. M., Hamidian, M., Howden, B. P., Lohr, I. H. & Holt, K. E. (2019). Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 74 (3), pp.577-581. https://doi.org/10.1093/jac/dky492.
Access StatusOpen Access
NHMRC Grant codeNHMRC/1105905
OBJECTIVES: Recent reports indicate the emergence of a new carbapenemase-producing Klebsiella pneumoniae clone, ST307. We sought to better understand the global epidemiology and evolution of this clone and evaluate its association with antimicrobial resistance (AMR) genes. METHODS: We collated information from the literature and public databases and performed a comparative analysis of 95 ST307 genomes (including 37 that were newly sequenced). RESULTS: We show that ST307 emerged in the mid-1990s (nearly 20 years prior to its first report), is already globally distributed and is intimately associated with a conserved plasmid harbouring the blaCTX-M-15 ESBL gene and several other AMR determinants. CONCLUSIONS: Our findings support the need for enhanced surveillance of this widespread ESBL clone in which carbapenem resistance has occasionally emerged.
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