Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307

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Wyres, KL; Hawkey, J; Hetland, MAK; Fostervold, A; Wick, RR; Judd, LM; Hamidian, M; Howden, BP; Lohr, IH; Holt, KEDate
2019-03-01Source Title
Journal of Antimicrobial ChemotherapyPublisher
OXFORD UNIV PRESSUniversity of Melbourne Author/s
Judd, Louise; Wick, Ryan; Howden, Benjamin; Holt, Kathryn; Wyres, Kelly; Hawkey, JaneAffiliation
Biochemistry and Molecular BiologyMicrobiology and Immunology
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Wyres, K. L., Hawkey, J., Hetland, M. A. K., Fostervold, A., Wick, R. R., Judd, L. M., Hamidian, M., Howden, B. P., Lohr, I. H. & Holt, K. E. (2019). Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 74 (3), pp.577-581. https://doi.org/10.1093/jac/dky492.Access Status
Open AccessAbstract
OBJECTIVES: Recent reports indicate the emergence of a new carbapenemase-producing Klebsiella pneumoniae clone, ST307. We sought to better understand the global epidemiology and evolution of this clone and evaluate its association with antimicrobial resistance (AMR) genes. METHODS: We collated information from the literature and public databases and performed a comparative analysis of 95 ST307 genomes (including 37 that were newly sequenced). RESULTS: We show that ST307 emerged in the mid-1990s (nearly 20 years prior to its first report), is already globally distributed and is intimately associated with a conserved plasmid harbouring the blaCTX-M-15 ESBL gene and several other AMR determinants. CONCLUSIONS: Our findings support the need for enhanced surveillance of this widespread ESBL clone in which carbapenem resistance has occasionally emerged.
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