The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa
AuthorPark, SE; Duy, TP; Boinett, C; Wong, VK; Pak, GD; Panzner, U; Espinoza, LMC; von Kalckreuth, V; Im, J; Schuett-Gerowitt, H; ...
Source TitleNature Communications
PublisherNATURE PUBLISHING GROUP
University of Melbourne Author/sHolt, Kathryn; Dougan, Gordon; Dyson, Zoe; Duchene Garzon, Sebastian
AffiliationBiochemistry and Molecular Biology
Microbiology and Immunology
Document TypeJournal Article
CitationsPark, S. E., Duy, T. P., Boinett, C., Wong, V. K., Pak, G. D., Panzner, U., Espinoza, L. M. C., von Kalckreuth, V., Im, J., Schuett-Gerowitt, H., Crump, J. A., Breiman, R. F., Adu-Sarkodie, Y., Owusu-Dabo, E., Rakotozandrindrainy, R., Soura, A. B., Aseffa, A., Gasmelseed, N., Keddy, K. H. ,... Baker, S. (2018). The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa. NATURE COMMUNICATIONS, 9 (1), https://doi.org/10.1038/s41467-018-07370-z.
Access StatusOpen Access
There is paucity of data regarding the geographical distribution, incidence, and phylogenetics of multi-drug resistant (MDR) Salmonella Typhi in sub-Saharan Africa. Here we present a phylogenetic reconstruction of whole genome sequenced 249 contemporaneous S. Typhi isolated between 2008-2015 in 11 sub-Saharan African countries, in context of the 2,057 global S. Typhi genomic framework. Despite the broad genetic diversity, the majority of organisms (225/249; 90%) belong to only three genotypes, 4.3.1 (H58) (99/249; 40%), 3.1.1 (97/249; 39%), and 2.3.2 (29/249; 12%). Genotypes 4.3.1 and 3.1.1 are confined within East and West Africa, respectively. MDR phenotype is found in over 50% of organisms restricted within these dominant genotypes. High incidences of MDR S. Typhi are calculated in locations with a high burden of typhoid, specifically in children aged <15 years. Antimicrobial stewardship, MDR surveillance, and the introduction of typhoid conjugate vaccines will be critical for the control of MDR typhoid in Africa.
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