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dc.contributor.authorHurley, JC
dc.date.accessioned2020-12-09T23:50:46Z
dc.date.available2020-12-09T23:50:46Z
dc.date.issued2018-03-01
dc.identifierpii: microorganisms6010018
dc.identifier.citationHurley, J. C. (2018). World-Wide Variation in Incidence of Staphylococcus aureus Associated Ventilator-Associated Pneumonia: A Meta-Regression. MICROORGANISMS, 6 (1), https://doi.org/10.3390/microorganisms6010018.
dc.identifier.issn2076-2607
dc.identifier.urihttp://hdl.handle.net/11343/253340
dc.description.abstractStaphylococcus aureus (S. aureus) is a common Ventilator-Associated Pneumonia (VAP) isolate. The objective here is to define the extent and possible reasons for geographic variation in the incidences of S. aureus-associated VAP, MRSA-VAP and overall VAP. A meta-regression model of S. aureus-associated VAP incidence per 1000 Mechanical Ventilation Days (MVD) was undertaken using random effects methods among publications obtained from a search of the English language literature. This model incorporated group level factors such as admission to a trauma ICU, year of publication and use of bronchoscopic sampling towards VAP diagnosis. The search identified 133 publications from seven worldwide regions published over three decades. The summary S. aureus-associated VAP incidence was 4.5 (3.9-5.3) per 1000 MVD. The highest S. aureus-associated VAP incidence is amongst reports from the Mediterranean (mean; 95% confidence interval; 6.1; 4.1-8.5) versus that from Asian ICUs (2.1; 1.5-3.0). The incidence of S. aureus-associated VAP varies by up to three-fold (for the lowest versus highest incidence) among seven geographic regions worldwide, whereas the incidence of VAP varies by less than two-fold. Admission to a trauma unit is the most important group level correlate for S. aureus-associated VAP.
dc.languageEnglish
dc.publisherMDPI
dc.titleWorld-Wide Variation in Incidence of Staphylococcus aureus Associated Ventilator-Associated Pneumonia: A Meta-Regression
dc.typeJournal Article
dc.identifier.doi10.3390/microorganisms6010018
melbourne.affiliation.departmentRural Clinical School
melbourne.source.titleMicroorganisms
melbourne.source.volume6
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1310995
melbourne.contributor.authorHurley, James
dc.identifier.eissn2076-2607
melbourne.accessrightsOpen Access


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