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    Characteristics of Epileptiform Discharge Duration and Interdischarge Interval in Genetic Generalized Epilepsies

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    Author
    Seneviratne, U; Boston, RC; Cook, MJ; D'Souza, WJ
    Date
    2018-02-19
    Source Title
    Frontiers in Neurology
    Publisher
    FRONTIERS MEDIA SA
    University of Melbourne Author/s
    Boston, Raymond; Cook, Mark; D'Souza, Wendyl; Seneviratne, Udaya
    Affiliation
    Medicine and Radiology
    Engineering
    Metadata
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    Document Type
    Journal Article
    Citations
    Seneviratne, U., Boston, R. C., Cook, M. J. & D'Souza, W. J. (2018). Characteristics of Epileptiform Discharge Duration and Interdischarge Interval in Genetic Generalized Epilepsies. FRONTIERS IN NEUROLOGY, 9 (FEB), https://doi.org/10.3389/fneur.2018.00036.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/253359
    DOI
    10.3389/fneur.2018.00036
    Abstract
    We sought to investigate (1) the characteristics of epileptiform discharge (ED) duration and interdischarge interval (IDI) and (2) the influence of vigilance state on the ED duration and IDI in genetic generalized epilepsy (GGE). In a cohort of patients diagnosed with GGE, 24-h ambulatory EEG recordings were performed prospectively. We then tabulated durations, IDI, and vigilance state in relation to all EDs captured on EEGs. We used K-means cluster analysis and finite mixture modeling to quantify and characterize the groups of ED duration and IDI. To investigate the influence of sleep, we calculated the mean, median, and SEM in each population from all subjects for sleep state and wakefulness separately, followed by the Kruskal-Wallis test to compare the groups. We analyzed 4,679 EDs and corresponding IDI from 23 abnormal 24-h ambulatory EEGs. Our analysis defined two populations of ED durations and IDI: short and long. In all populations, both ED durations and IDI were significantly longer in wakefulness. Our results highlight different characteristics of ED populations in GGE and the influence by the sleep-wake cycle.

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