Show simple item record

dc.contributor.authorSeneviratne, U
dc.contributor.authorBoston, RC
dc.contributor.authorCook, MJ
dc.contributor.authorD'Souza, WJ
dc.date.accessioned2020-12-09T23:54:36Z
dc.date.available2020-12-09T23:54:36Z
dc.date.issued2018-02-19
dc.identifier.citationSeneviratne, U., Boston, R. C., Cook, M. J. & D'Souza, W. J. (2018). Characteristics of Epileptiform Discharge Duration and Interdischarge Interval in Genetic Generalized Epilepsies. FRONTIERS IN NEUROLOGY, 9 (FEB), https://doi.org/10.3389/fneur.2018.00036.
dc.identifier.issn1664-2295
dc.identifier.urihttp://hdl.handle.net/11343/253359
dc.description.abstractWe sought to investigate (1) the characteristics of epileptiform discharge (ED) duration and interdischarge interval (IDI) and (2) the influence of vigilance state on the ED duration and IDI in genetic generalized epilepsy (GGE). In a cohort of patients diagnosed with GGE, 24-h ambulatory EEG recordings were performed prospectively. We then tabulated durations, IDI, and vigilance state in relation to all EDs captured on EEGs. We used K-means cluster analysis and finite mixture modeling to quantify and characterize the groups of ED duration and IDI. To investigate the influence of sleep, we calculated the mean, median, and SEM in each population from all subjects for sleep state and wakefulness separately, followed by the Kruskal-Wallis test to compare the groups. We analyzed 4,679 EDs and corresponding IDI from 23 abnormal 24-h ambulatory EEGs. Our analysis defined two populations of ED durations and IDI: short and long. In all populations, both ED durations and IDI were significantly longer in wakefulness. Our results highlight different characteristics of ED populations in GGE and the influence by the sleep-wake cycle.
dc.languageEnglish
dc.publisherFRONTIERS MEDIA SA
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleCharacteristics of Epileptiform Discharge Duration and Interdischarge Interval in Genetic Generalized Epilepsies
dc.typeJournal Article
dc.identifier.doi10.3389/fneur.2018.00036
melbourne.affiliation.departmentEngineering and Information Technology
melbourne.affiliation.departmentMedicine (St Vincent's)
melbourne.affiliation.facultyEngineering and Information Technology
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleFrontiers in Neurology
melbourne.source.volume9
melbourne.source.issueFEB
dc.rights.licenseCC BY
melbourne.elementsid1311895
melbourne.contributor.authorBoston, Raymond
melbourne.contributor.authorCook, Mark
melbourne.contributor.authorD'Souza, Wendyl
melbourne.contributor.authorSeneviratne, Udaya
dc.identifier.eissn1664-2295
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record