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dc.contributor.authorSethi, K
dc.contributor.authorRao, K
dc.contributor.authorBolton, D
dc.contributor.authorPatel, O
dc.contributor.authorIschia, J
dc.date.accessioned2020-12-09T23:59:49Z
dc.date.available2020-12-09T23:59:49Z
dc.date.issued2018
dc.identifier.citationSethi, K., Rao, K., Bolton, D., Patel, O. & Ischia, J. (2018). Targeting HIF-1α to Prevent Renal Ischemia-Reperfusion Injury: Does It Work?. Int J Cell Biol, 2018, pp.9852791-. https://doi.org/10.1155/2018/9852791.
dc.identifier.issn1687-8876
dc.identifier.urihttp://hdl.handle.net/11343/253386
dc.description.abstractPartial nephrectomy (open or minimally invasive) usually requires temporary renal arterial occlusion to limit intraoperative bleeding and improve access to intrarenal structures. This is a time-critical step due to the critical ischemia period of renal tissue. Prolonged renal ischemia may lead to irreversible nephron damage in the remaining tissue and, ultimately, chronic kidney disease. This is potentiated by the incompletely understood ischemia-reperfusion injury (IRI). A key mechanism in IRI prevention appears to be the upregulation of an intracellular transcription protein, Hypoxia-Inducible Factor (HIF). HIF mediates metabolic adaptation, angiogenesis, erythropoiesis, cell growth, survival, and apoptosis. Upregulating HIF-1α via ischemic preconditioning (IPC) or drugs that simulate hypoxia (hypoxia-mimetics) has been investigated as a method to reduce IRI. While many promising chemical agents have been trialed for the prevention of IRI in small animal studies, all have failed in human trials. The aim of this review is to highlight the techniques and drugs that target HIF-1α and ameliorate IRI associated with renal ischemia. Developing a technique or drug that could reduce the risk of acute kidney injury associated with renal IRI would have an immediate worldwide impact on multisystem surgeries that would otherwise risk ischemic tissue injury.
dc.languageeng
dc.publisherHindawi Limited
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleTargeting HIF-1α to Prevent Renal Ischemia-Reperfusion Injury: Does It Work?
dc.typeJournal Article
dc.identifier.doi10.1155/2018/9852791
melbourne.affiliation.departmentSurgery (St Vincent's)
melbourne.affiliation.departmentSurgery (Austin & Northern Health)
melbourne.affiliation.department
melbourne.source.titleInternational Journal of Cell Biology
melbourne.source.volume2018
melbourne.source.pages9852791-
dc.rights.licenseCC BY
melbourne.elementsid1363347
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286753
melbourne.contributor.authorPatel, Oneel
melbourne.contributor.authorIschia, Joseph
melbourne.contributor.authorBolton, Damien
melbourne.contributor.authorSethi, Kapil
melbourne.contributor.authorRAO, KENNY
melbourne.contributor.authorSethi, Kapil
dc.identifier.eissn1687-8884
melbourne.accessrightsOpen Access


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