Show simple item record

dc.contributor.authorSteigedal, TS
dc.contributor.authorToraskar, J
dc.contributor.authorRedvers, RP
dc.contributor.authorValla, M
dc.contributor.authorMagnussen, SN
dc.contributor.authorBofin, AM
dc.contributor.authorOpdahl, S
dc.contributor.authorLundgren, S
dc.contributor.authorEckhardt, BL
dc.contributor.authorLamar, JM
dc.contributor.authorDoherty, J
dc.contributor.authorHynes, RO
dc.contributor.authorAnderson, RL
dc.contributor.authorSvineng, G
dc.date.accessioned2020-12-10T00:02:51Z
dc.date.available2020-12-10T00:02:51Z
dc.date.issued2018-04-01
dc.identifierpii: S1476-5586(17)30546-8
dc.identifier.citationSteigedal, T. S., Toraskar, J., Redvers, R. P., Valla, M., Magnussen, S. N., Bofin, A. M., Opdahl, S., Lundgren, S., Eckhardt, B. L., Lamar, J. M., Doherty, J., Hynes, R. O., Anderson, R. L. & Svineng, G. (2018). Nephronectin is Correlated with Poor Prognosis in Breast Cancer and Promotes Metastasis via its Integrin-Binding Motifs. NEOPLASIA, 20 (4), pp.387-400. https://doi.org/10.1016/j.neo.2018.02.008.
dc.identifier.issn1476-5586
dc.identifier.urihttp://hdl.handle.net/11343/253399
dc.description.abstractMost cancer patients with solid tumors who succumb to their illness die of metastatic disease. While early detection and improved treatment have led to reduced mortality, even for those with metastatic cancer, some patients still respond poorly to treatment. Understanding the mechanisms of metastasis is important to improve prognostication, to stratify patients for treatment, and to identify new targets for therapy. We have shown previously that expression of nephronectin (NPNT) is correlated with metastatic propensity in breast cancer cell lines. In the present study, we provide a comprehensive analysis of the expression pattern and distribution of NPNT in breast cancer tissue from 842 patients by immunohistochemical staining of tissue microarrays from a historic cohort. Several patterns of NPNT staining were observed. An association between granular cytoplasmic staining (in <10% of tumor cells) and poor prognosis was found. We suggest that granular cytoplasmic staining may represent NPNT-positive exosomes. We found that NPNT promotes adhesion and anchorage-independent growth via its integrin-binding and enhancer motifs and that enforced expression in breast tumor cells promotes their colonization of the lungs. We propose that NPNT may be a novel prognostic marker in a subgroup of breast cancer patients.
dc.languageEnglish
dc.publisherELSEVIER SCIENCE INC
dc.titleNephronectin is Correlated with Poor Prognosis in Breast Cancer and Promotes Metastasis via its Integrin-Binding Motifs
dc.typeJournal Article
dc.identifier.doi10.1016/j.neo.2018.02.008
melbourne.affiliation.departmentSir Peter MacCallum Department of Oncology
melbourne.source.titleNeoplasia
melbourne.source.volume20
melbourne.source.issue4
melbourne.source.pages387-400
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1313753
melbourne.contributor.authorAnderson, Robin
dc.identifier.eissn1476-5586
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record