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dc.contributor.authorMatejcic, M
dc.contributor.authorSaunders, EJ
dc.contributor.authorDadaev, T
dc.contributor.authorBrook, MN
dc.contributor.authorWang, K
dc.contributor.authorSheng, X
dc.contributor.authorAl Olama, AA
dc.contributor.authorSchumacher, FR
dc.contributor.authorIngles, SA
dc.contributor.authorGovindasami, K
dc.contributor.authorBenlloch, S
dc.contributor.authorBerndt, S
dc.contributor.authorAlbanes, D
dc.contributor.authorKoutros, S
dc.contributor.authorMuir, K
dc.contributor.authorStevens, VL
dc.contributor.authorGapstur, SM
dc.contributor.authorTangen, CM
dc.contributor.authorBatra, J
dc.contributor.authorClements, J
dc.contributor.authorGronberg, H
dc.contributor.authorPashayan, N
dc.contributor.authorSchleutker, J
dc.contributor.authorWolk, A
dc.contributor.authorWest, C
dc.contributor.authorMucci, L
dc.contributor.authorKraft, P
dc.contributor.authorCancel-Tassin, G
dc.contributor.authorSorensen, KD
dc.contributor.authorMaehle, L
dc.contributor.authorGrindedal, EM
dc.contributor.authorStrom, SS
dc.contributor.authorNeal, DE
dc.contributor.authorHamdy, FC
dc.contributor.authorDonovan, JL
dc.contributor.authorTravis, RC
dc.contributor.authorHamilton, RJ
dc.contributor.authorRosenstein, B
dc.contributor.authorLu, Y-J
dc.contributor.authorGiles, GG
dc.contributor.authorKibel, AS
dc.contributor.authorVega, A
dc.contributor.authorBensen, JT
dc.contributor.authorKogevinas, M
dc.contributor.authorPenney, KL
dc.contributor.authorPark, JY
dc.contributor.authorStanford, JL
dc.contributor.authorCybulski, C
dc.contributor.authorNordestgaard, BG
dc.contributor.authorBrenner, H
dc.contributor.authorMaier, C
dc.contributor.authorKim, J
dc.contributor.authorTeixeira, MR
dc.contributor.authorNeuhausen, SL
dc.contributor.authorDe Ruyck, K
dc.contributor.authorRazack, A
dc.contributor.authorNewcomb, LF
dc.contributor.authorLessel, D
dc.contributor.authorKaneva, R
dc.contributor.authorUsmani, N
dc.contributor.authorClaessens, F
dc.contributor.authorTownsend, PA
dc.contributor.authorDominguez, MG
dc.contributor.authorRoobol, MJ
dc.contributor.authorMenegaux, F
dc.contributor.authorKhaw, K-T
dc.contributor.authorCannon-Albright, LA
dc.contributor.authorPandha, H
dc.contributor.authorThibodeau, SN
dc.contributor.authorSchaid, DJ
dc.contributor.authorWiklund, F
dc.contributor.authorChanock, SJ
dc.contributor.authorEaston, DF
dc.contributor.authorEeles, RA
dc.contributor.authorKote-Jarai, Z
dc.contributor.authorConti, D
dc.contributor.authorHaiman, CA
dc.date.accessioned2020-12-10T00:04:54Z
dc.date.available2020-12-10T00:04:54Z
dc.date.issued2018-11-05
dc.identifierpii: 10.1038/s41467-018-06863-1
dc.identifier.citationMatejcic, M., Saunders, E. J., Dadaev, T., Brook, M. N., Wang, K., Sheng, X., Al Olama, A. A., Schumacher, F. R., Ingles, S. A., Govindasami, K., Benlloch, S., Berndt, S., Albanes, D., Koutros, S., Muir, K., Stevens, V. L., Gapstur, S. M., Tangen, C. M., Batra, J. ,... Haiman, C. A. (2018). Germline variation at 8q24 and prostate cancer risk in men of European ancestry. NATURE COMMUNICATIONS, 9 (1), https://doi.org/10.1038/s41467-018-06863-1.
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/11343/253409
dc.description.abstractChromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p < 4.28 × 10-15), including three risk variants that have yet to be reported. From a polygenic risk score (PRS) model, derived to assess the cumulative effect of risk variants at 8q24, men in the top 1% of the PRS have a 4-fold (95%CI = 3.62-4.40) greater risk compared to the population average. These 12 variants account for ~25% of what can be currently explained of the familial risk of prostate cancer by known genetic risk factors. These findings highlight the overwhelming contribution of germline variation at 8q24 on prostate cancer risk which has implications for population risk stratification.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleGermline variation at 8q24 and prostate cancer risk in men of European ancestry
dc.typeJournal Article
dc.identifier.doi10.1038/s41467-018-06863-1
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.affiliation.departmentClinical Pathology
melbourne.affiliation.departmentSir Peter MacCallum Department of Oncology
melbourne.affiliation.departmentUniversity General
melbourne.source.titleNature Communications
melbourne.source.volume9
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1357437
melbourne.contributor.authorGiles, Graham
melbourne.contributor.authorMacInnis, Robert
melbourne.contributor.authorElliott, Rebecca
melbourne.contributor.authorMilne, Roger
dc.identifier.eissn2041-1723
melbourne.identifier.fundernameidCANCER COUNCIL VICTORIA, 1074383
melbourne.accessrightsOpen Access


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