Show simple item record

dc.contributor.authorFadlyana, E
dc.contributor.authorDunne, EM
dc.contributor.authorRusmil, K
dc.contributor.authorTarigan, R
dc.contributor.authorSudigdoadi, S
dc.contributor.authorMurad, C
dc.contributor.authorWatts, E
dc.contributor.authorNguyen, C
dc.contributor.authorSatzke, C
dc.contributor.authorDewi, NE
dc.contributor.authorIndriyani, SAK
dc.contributor.authorYani, FF
dc.contributor.authorMulholland, K
dc.contributor.authorKartasasmita, C
dc.date.accessioned2020-12-10T00:09:56Z
dc.date.available2020-12-10T00:09:56Z
dc.date.issued2018-12-25
dc.identifierpii: 58
dc.identifier.citationFadlyana, E., Dunne, E. M., Rusmil, K., Tarigan, R., Sudigdoadi, S., Murad, C., Watts, E., Nguyen, C., Satzke, C., Dewi, N. E., Indriyani, S. A. K., Yani, F. F., Mulholland, K. & Kartasasmita, C. (2018). Risk factors associated with nasopharyngeal carriage and density of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus in young children living in Indonesia. PNEUMONIA, 10 (1), https://doi.org/10.1186/s41479-018-0058-1.
dc.identifier.issn2200-6133
dc.identifier.urihttp://hdl.handle.net/11343/253430
dc.description.abstractBackground: Potentially pathogenic bacteria Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus are commonly carried in the nasopharynx of young children. Host and environmental factors have been linked with pathogen carriage, and in many studies rural children have higher carriage rates than their urban counterparts. There are few published data on what factors contribute to increased pathogen density. The objectives of this study were to identify risk factors for nasopharyngeal carriage and density of S. pneumoniae, H. influenzae, M. catarrhalis, and S. aureus in young children in Indonesia. Methods: Risk factor analysis was done using data on bacterial carriage and participant characteristics from a cross-sectional study that enrolled 302 children aged 12-24 months living in urban or semi-rural areas of Indonesia. Associations between host factors and odds of pathogen carriage were explored using logistic regression. Characteristics identified to be independent predictors of carriage by univariable analysis, as well as those that differed between urban and semi-rural participants, were included in multivariable models. Risk factors for increased pathogen density were identified using linear regression analysis. Results: No differences in carriage prevalence between urban and semi-rural children were observed. Multiple children under the age of 5 years in the household (< 5y) and upper respiratory tract infection (URTI) symptoms were associated with S. pneumoniae carriage, with adjusted odds ratios (aOR) of 2.17 (95% CI 1.13, 4.12) and 2.28 (95% CI 1.15, 4.50), respectively. There was some evidence that URTI symptoms (aOR 1.94 [95% CI 1.00, 3.75]) were associated with carriage of M. catarrhalis. Children with URTI symptoms (p = 0.002), and low parental income (p = 0.011) had higher S. pneumoniae density, whereas older age was associated with lower S. pneumoniae density (p = 0.009). URTI symptoms were also associated with higher M. catarrahlis density (p = 0.035). Low maternal education (p = 0.039) and multiple children < 5y (p = 0.021) were positively associated with H. influenzae density, and semi-rural residence was associated with higher S. aureus density (p < 0.001). Conclusions: This study provides a detailed assessment of risk factors associated with carriage of clinically-relevant bacteria in Indonesian children, and new data on host factors associated with pathogen density.
dc.languageEnglish
dc.publisherGRIFFITH UNIV EPRESS
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleRisk factors associated with nasopharyngeal carriage and density of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus in young children living in Indonesia
dc.typeJournal Article
dc.identifier.doi10.1186/s41479-018-0058-1
melbourne.affiliation.departmentPaediatrics (RCH)
melbourne.affiliation.departmentUniversity General
melbourne.source.titlePneumonia
melbourne.source.volume10
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1364297
melbourne.contributor.authorMulholland, Kim
melbourne.contributor.authorSatzke, Catherine
melbourne.contributor.authorNguyen, Cattram
melbourne.contributor.authorDunne, Eileen
dc.identifier.eissn2200-6133
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record