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dc.contributor.authorSamkani, A
dc.contributor.authorSkytte, MJ
dc.contributor.authorAnholm, C
dc.contributor.authorAstrup, A
dc.contributor.authorDeacon, CF
dc.contributor.authorHolst, JJ
dc.contributor.authorMadsbad, S
dc.contributor.authorBoston, R
dc.contributor.authorKrarup, T
dc.contributor.authorHaugaard, SB
dc.date.accessioned2020-12-10T00:19:38Z
dc.date.available2020-12-10T00:19:38Z
dc.date.issued2018-12-27
dc.identifierpii: 10.1186/s12944-018-0953-8
dc.identifier.citationSamkani, A., Skytte, M. J., Anholm, C., Astrup, A., Deacon, C. F., Holst, J. J., Madsbad, S., Boston, R., Krarup, T. & Haugaard, S. B. (2018). The acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides: a randomized trial. LIPIDS IN HEALTH AND DISEASE, 17 (1), https://doi.org/10.1186/s12944-018-0953-8.
dc.identifier.issn1476-511X
dc.identifier.urihttp://hdl.handle.net/11343/253460
dc.description.abstractBACKGROUND: Postprandial non-esterified fatty acid (NEFA) and triglyceride (TG) responses are increased in subjects with type 2 diabetes mellitus (T2DM) and may impair insulin action and increase risk of cardiovascular disease and death. Dietary carbohydrate reduction has been suggested as non-pharmacological therapy for T2DM, but the acute effects on NEFA and TG during subsequent meals remain to be investigated. METHODS: Postprandial NEFA and TG responses were assessed in subjects with T2DM by comparing a carbohydrate-reduced high-protein (CRHP) diet with a conventional diabetes (CD) diet in an open-label, randomized, cross-over study. Each diet was consumed on two consecutive days, separated by a wash-out period. The iso-caloric CRHP/CD diets contained 31/54 E% from carbohydrate, 29/16 E% energy from protein and 40/30 E% from fat, respectively. Sixteen subjects with well-controlled T2DM (median HbA1c 47 mmol/mol, (37-67 mmol/mol) and BMI 30 ± 4.4 kg/m2) participated in the study. NEFA and TG were evaluated following breakfast and lunch. RESULTS: NEFA net area under curve (AUC) was increased by 97 ± 38 μmol/Lx270 min (p = 0.024) after breakfast but reduced by 141 ± 33 μmol/Lx180 min (p < 0.001) after lunch on the CRHP compared with CD diet. Likewise, TG net AUC was increased by 80 ± 28 μmol/Lx270 min (p = 0.012) after breakfast but reduced by 320 ± 60 μmol/Lx180 min (p < 0.001) after lunch on the CRHP compared with CD diet. CONCLUSIONS: In well-controlled T2DM a modest reduction of dietary carbohydrate with a corresponding increase in protein and fat acutely reduced postprandial serum NEFA suppression and increased serum TG responses after a breakfast meal but had the opposite effect after a lunch meal. The mechanism behind this second-meal phenomenon of CRHP diet on important risk factors for aggravating T2DM and cardiovascular disease awaits further investigation. TRIAL REGISTRATION: The study was registered at clinicaltrials.gov ID: NCT02472951. https://clinicaltrials.gov/ct2/show/NCT02472951 . Registered June 16, 2015.
dc.languageEnglish
dc.publisherBMC
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleThe acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides: a randomized trial
dc.typeJournal Article
dc.identifier.doi10.1186/s12944-018-0953-8
melbourne.affiliation.departmentMedicine (St Vincent's)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleLipids in Health and Disease
melbourne.source.volume17
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1365467
melbourne.contributor.authorBoston, Raymond
dc.identifier.eissn1476-511X
melbourne.accessrightsOpen Access


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