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    A Novel Cellular Pathway of Antigen Presentation and CD4 T Cell Activation in vivo

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    Author
    Scales, HE; Meehan, GR; Hayes, AJ; Benson, RA; Watson, E; Walters, A; Tomura, M; Maraskovsky, E; Garside, P; Morelli, AB; ...
    Date
    2018-11-22
    Source Title
    Frontiers in Immunology
    Publisher
    FRONTIERS MEDIA SA
    University of Melbourne Author/s
    Maraskovsky, Eugene
    Affiliation
    Medicine and Radiology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Scales, H. E., Meehan, G. R., Hayes, A. J., Benson, R. A., Watson, E., Walters, A., Tomura, M., Maraskovsky, E., Garside, P., Morelli, A. B. & Brewer, J. M. (2018). A Novel Cellular Pathway of Antigen Presentation and CD4 T Cell Activation in vivo. FRONTIERS IN IMMUNOLOGY, 9 (NOV), https://doi.org/10.3389/fimmu.2018.02684.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/253467
    DOI
    10.3389/fimmu.2018.02684
    Abstract
    Dendritic cell activation of CD4 T cells in the lymph node draining a site of infection or vaccination is widely considered the central event in initiating adaptive immunity. The accepted dogma is that this occurs by stimulating local activation and antigen acquisition by dendritic cells, with subsequent lymph node migration, however the generalizability of this mechanism is unclear. Here we show that in some circumstances antigen can bypass the injection site inflammatory response, draining freely and rapidly to the lymph nodes where it interacts with subcapsular sinus (SCS) macrophages resulting in their death. Debris from these dying SCS macrophages is internalized by monocytes recruited from the circulation. This coordinated response leads to antigen presentation by monocytes and interactions with naïve CD4 T cells that can drive the initiation of T cell and B cell responses. These studies demonstrate an entirely novel pathway leading to initiation of adaptive immune responses in vivo.

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