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dc.contributor.authorFlores-Opazo, M
dc.contributor.authorBoland, E
dc.contributor.authorGarnham, A
dc.contributor.authorMurphy, RM
dc.contributor.authorMcGee, SL
dc.contributor.authorHargreaves, M
dc.date.accessioned2020-12-10T00:21:48Z
dc.date.available2020-12-10T00:21:48Z
dc.date.issued2018-11-01
dc.identifier.citationFlores-Opazo, M., Boland, E., Garnham, A., Murphy, R. M., McGee, S. L. & Hargreaves, M. (2018). Exercise and GLUT4 in human subcutaneous adipose tissue. PHYSIOLOGICAL REPORTS, 6 (22), https://doi.org/10.14814/phy2.13918.
dc.identifier.issn2051-817X
dc.identifier.urihttp://hdl.handle.net/11343/253469
dc.description.abstractTo examine the effect of acute and chronic exercise on adipose tissue GLUT4 expression, a total of 20 healthy, male subjects performed one of two studies. Ten subjects performed cycle ergometer exercise for 60 min at 73 ± 2% VO2 peak and abdominal adipose tissue samples were obtained immediately before and after exercise and after 3 h of recovery. Another 10 subjects completed 10 days of exercise training, comprising a combination of six sessions of 60 min at 75% VO2 peak and four sessions of 6 × 5 min at 90% VO2 peak, separated by 3 min at 40% VO2 peak. Abdominal adipose tissue and vastus lateralis muscle samples were obtained before training and 24 h after the last training session. A single bout of exercise did not change adipose tissue GLUT4 mRNA; however, there was a small, but significant, reduction in adipose tissue GLUT4 protein expression 3 h after exercise. There were no changes in adipose tissue GLUT4 or COX-IV expression following exercise training. In contrast, skeletal muscle GLUT4 and COX-IV were increased by 47% and 44%, respectively following exercise training. The exercise training-induced increase in GLUT4 expression was similar in both type I and type IIa single muscle fibers. Our results indicate that neither a single exercise bout, nor 10 days of exercise training, increased adipose tissue GLUT4, in contrast with the increases observed in skeletal muscle GLUT4 expression.
dc.languageEnglish
dc.publisherWILEY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleExercise and GLUT4 in human subcutaneous adipose tissue
dc.typeJournal Article
dc.identifier.doi10.14814/phy2.13918
melbourne.affiliation.departmentChancellery Research
melbourne.source.titlePhysiological Reports
melbourne.source.volume6
melbourne.source.issue22
dc.rights.licenseCC BY
melbourne.elementsid1359100
melbourne.contributor.authorHargreaves, Ian
dc.identifier.eissn2051-817X
melbourne.accessrightsOpen Access


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