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dc.contributor.authorFlores-Opazo, M
dc.contributor.authorBoland, E
dc.contributor.authorGarnham, A
dc.contributor.authorMurphy, RM
dc.contributor.authorMcGee, SL
dc.contributor.authorHargreaves, M
dc.date.accessioned2020-12-10T00:21:48Z
dc.date.available2020-12-10T00:21:48Z
dc.date.issued2018-11-01
dc.identifier.citationFlores-Opazo, M., Boland, E., Garnham, A., Murphy, R. M., McGee, S. L. & Hargreaves, M. (2018). Exercise and GLUT4 in human subcutaneous adipose tissue. PHYSIOLOGICAL REPORTS, 6 (22), https://doi.org/10.14814/phy2.13918.
dc.identifier.issn2051-817X
dc.identifier.urihttp://hdl.handle.net/11343/253469
dc.description.abstractTo examine the effect of acute and chronic exercise on adipose tissue GLUT4 expression, a total of 20 healthy, male subjects performed one of two studies. Ten subjects performed cycle ergometer exercise for 60 min at 73 ± 2% VO2 peak and abdominal adipose tissue samples were obtained immediately before and after exercise and after 3 h of recovery. Another 10 subjects completed 10 days of exercise training, comprising a combination of six sessions of 60 min at 75% VO2 peak and four sessions of 6 × 5 min at 90% VO2 peak, separated by 3 min at 40% VO2 peak. Abdominal adipose tissue and vastus lateralis muscle samples were obtained before training and 24 h after the last training session. A single bout of exercise did not change adipose tissue GLUT4 mRNA; however, there was a small, but significant, reduction in adipose tissue GLUT4 protein expression 3 h after exercise. There were no changes in adipose tissue GLUT4 or COX-IV expression following exercise training. In contrast, skeletal muscle GLUT4 and COX-IV were increased by 47% and 44%, respectively following exercise training. The exercise training-induced increase in GLUT4 expression was similar in both type I and type IIa single muscle fibers. Our results indicate that neither a single exercise bout, nor 10 days of exercise training, increased adipose tissue GLUT4, in contrast with the increases observed in skeletal muscle GLUT4 expression.
dc.languageEnglish
dc.publisherWILEY
dc.titleExercise and GLUT4 in human subcutaneous adipose tissue
dc.typeJournal Article
dc.identifier.doi10.14814/phy2.13918
melbourne.affiliation.departmentChancellery Research
melbourne.source.titlePhysiological Reports
melbourne.source.volume6
melbourne.source.issue22
dc.rights.licenseCC BY
melbourne.elementsid1359100
melbourne.contributor.authorHargreaves, Ian
dc.identifier.eissn2051-817X
melbourne.accessrightsOpen Access


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