The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles.
AuthorOrme, MH; Liccardi, G; Moderau, N; Feltham, R; Wicky-John, S; Tenev, T; Aram, L; Wilson, R; Bianchi, K; Morris, O; ...
Source TitleNature Communications
PublisherSpringer Science and Business Media LLC
University of Melbourne Author/sFeltham, Rebecca
AffiliationMedical Biology (W.E.H.I.)
Document TypeJournal Article
CitationsOrme, M. H., Liccardi, G., Moderau, N., Feltham, R., Wicky-John, S., Tenev, T., Aram, L., Wilson, R., Bianchi, K., Morris, O., Monteiro Domingues, C., Robertson, D., Tare, M., Wepf, A., Williams, D., Bergmann, A., Gstaiger, M., Arama, E., Ribeiro, P. S. & Meier, P. (2016). The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles.. Nat Commun, 7 (1), pp.10972-. https://doi.org/10.1038/ncomms10972.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792956
Caspases provide vital links in non-apoptotic regulatory networks controlling inflammation, compensatory proliferation, morphology and cell migration. How caspases are activated under non-apoptotic conditions and process a selective set of substrates without killing the cell remain enigmatic. Here we find that the Drosophila unconventional myosin CRINKLED (CK) selectively interacts with the initiator caspase DRONC and regulates some of its non-apoptotic functions. Loss of CK in the arista, border cells or proneural clusters of the wing imaginal discs affects DRONC-dependent patterning. Our data indicate that CK acts as substrate adaptor, recruiting SHAGGY46/GSK3-β to DRONC, thereby facilitating caspase-mediated cleavage and localized modulation of kinase activity. Similarly, the mammalian CK counterpart, MYO7A, binds to and impinges on CASPASE-8, revealing a new regulatory axis affecting receptor interacting protein kinase-1 (RIPK1)>CASPASE-8 signalling. Together, our results expose a conserved role for unconventional myosins in transducing caspase-dependent regulation of kinases, allowing them to take part in specific signalling events.
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References