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dc.contributor.authorKoay, H-F
dc.contributor.authorGodfrey, DI
dc.contributor.authorPellicci, DG
dc.date.accessioned2020-12-10T00:28:45Z
dc.date.available2020-12-10T00:28:45Z
dc.date.issued2018-07-01
dc.identifier.citationKoay, H. -F., Godfrey, D. I. & Pellicci, D. G. (2018). Development of mucosal-associated invariant T cells. IMMUNOLOGY AND CELL BIOLOGY, 96 (6), pp.598-606. https://doi.org/10.1111/imcb.12039.
dc.identifier.issn0818-9641
dc.identifier.urihttp://hdl.handle.net/11343/253501
dc.description.abstractMucosal-associated invariant T (MAIT) cells develop in the thymus and migrate into the periphery to become the largest antigen-specific αβ T-cell population in the human immune system. However, the frequency of MAIT cells varies widely between human individuals, and the basis for this is unclear. While MAIT cells are highly conserved through evolution and are phenotypically similar between humans and mice, they represent a much smaller proportion of total T cells in mice. In this review, we discuss how MAIT cells transition through a three-stage development pathway in both mouse and human thymus, and continue to mature and expand after they leave the thymus. Moreover, we will explore and speculate on how specific factors regulate different stages of this process.
dc.languageEnglish
dc.publisherWILEY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleDevelopment of mucosal-associated invariant T cells
dc.typeJournal Article
dc.identifier.doi10.1111/imcb.12039
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.source.titleImmunology and Cell Biology
melbourne.source.volume96
melbourne.source.issue6
melbourne.source.pages598-606
melbourne.identifier.nhmrc1020770
melbourne.identifier.nhmrc1117766
melbourne.identifier.nhmrc1122890
melbourne.identifier.nhmrc1144308
melbourne.identifier.nhmrc1140126
melbourne.identifier.nhmrc1145373
dc.rights.licenseCC BY
melbourne.elementsid1320120
melbourne.contributor.authorGodfrey, Dale
melbourne.contributor.authorPellicci, Daniel
melbourne.contributor.authorKoay, Hui Fern
dc.identifier.eissn1440-1711
melbourne.identifier.fundernameidNHMRC, 1020770
melbourne.identifier.fundernameidNHMRC, 1117766
melbourne.identifier.fundernameidNHMRC, 1122890
melbourne.identifier.fundernameidNHMRC, 1144308
melbourne.identifier.fundernameidNHMRC, 1140126
melbourne.identifier.fundernameidNHMRC, 1145373
melbourne.accessrightsOpen Access


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