Management of post-traumatic epilepsy: An evidence review over the last 5 years and future directions.

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Author
Piccenna, L; Shears, G; O'Brien, TJDate
2017-06Source Title
Epilepsia OpenPublisher
WileyUniversity of Melbourne Author/s
O'Brien, TerenceAffiliation
Medicine and RadiologyMetadata
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Journal ArticleCitations
Piccenna, L., Shears, G. & O'Brien, T. J. (2017). Management of post-traumatic epilepsy: An evidence review over the last 5 years and future directions.. Epilepsia Open, 2 (2), pp.123-144. https://doi.org/10.1002/epi4.12049.Access Status
Open AccessOpen Access at PMC
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719843Abstract
Post-traumatic epilepsy (PTE) is a relatively underappreciated condition that can develop as a secondary consequence following traumatic brain injury (TBI). The aim of this rapid evidence review is to provide a synthesis of existing evidence on the effectiveness of treatment interventions for the prevention of PTE in people who have suffered a moderate/severe TBI to increase awareness and understanding among consumers. Electronic medical databases (n = 5) and gray literature published between January 2010 and April 2015 were searched for studies on the management of PTE. Twenty-two eligible studies were identified that met the inclusion criteria. No evidence was found for the effectiveness of any pharmacological treatments in the prevention or treatment of symptomatic seizures in adults with PTE. However, limited high-level evidence for the effectiveness of the antiepileptic drug levetiracetam was identified for PTE in children. Low-level evidence was identified for nonpharmacological interventions in significantly reducing seizures in patients with PTE, but only in a minority of cases, requiring further high-level studies to confirm the results. This review provides an opportunity for researchers and health service professionals to better understand the underlying pathophysiology of PTE to develop novel, more effective therapeutic targets and to improve the quality of life of people with this condition.
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