Adjuvanting a viral vectored vaccine against pre-erythrocytic malaria
Web of Science
AuthorMilicic, A; Rollier, CS; Tang, CK; Longley, R; Hill, AVS; Reyes-Sandoval, A
Source TitleScientific Reports
PublisherNATURE PUBLISHING GROUP
University of Melbourne Author/sLongley, Rhea
AffiliationMedical Biology (W.E.H.I.)
Document TypeJournal Article
CitationsMilicic, A., Rollier, C. S., Tang, C. K., Longley, R., Hill, A. V. S. & Reyes-Sandoval, A. (2017). Adjuvanting a viral vectored vaccine against pre-erythrocytic malaria. SCIENTIFIC REPORTS, 7 (1), https://doi.org/10.1038/s41598-017-07246-0.
Access StatusOpen Access
The majority of routinely given vaccines require two or three immunisations for full protective efficacy. Single dose vaccination has long been considered a key solution to improving the global immunisation coverage. Recent infectious disease outbreaks have further highlighted the need for vaccines that can achieve full efficacy after a single administration. Viral vectors are a potent immunisation platform, benefiting from intrinsic immuno-stimulatory features while retaining excellent safety profile through the use of non-replicating viruses. We investigated the scope for enhancing the protective efficacy of a single dose adenovirus-vectored malaria vaccine in a mouse model of malaria by co-administering it with vaccine adjuvants. Out of 11 adjuvants, only two, Abisco®-100 and CoVaccineHTTM, enhanced vaccine efficacy and sterile protection following malaria challenge. The CoVaccineHTTM adjuvanted vaccine induced significantly higher proportion of antigen specific central memory CD8+ cells, and both adjuvants resulted in increased proportion of CD8+ T cells expressing the CD107a degranulation marker in the absence of IFNγ, TNFα and IL2 production. Our results show that the efficacy of vaccines designed to induce protective T cell responses can be positively modulated with chemical adjuvants and open the possibility of achieving full protection with a single dose immunisation.
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