dc.contributor.author | Milicic, A | |
dc.contributor.author | Rollier, CS | |
dc.contributor.author | Tang, CK | |
dc.contributor.author | Longley, R | |
dc.contributor.author | Hill, AVS | |
dc.contributor.author | Reyes-Sandoval, A | |
dc.date.accessioned | 2020-12-10T00:36:58Z | |
dc.date.available | 2020-12-10T00:36:58Z | |
dc.date.issued | 2017-08-04 | |
dc.identifier | pii: 10.1038/s41598-017-07246-0 | |
dc.identifier.citation | Milicic, A., Rollier, C. S., Tang, C. K., Longley, R., Hill, A. V. S. & Reyes-Sandoval, A. (2017). Adjuvanting a viral vectored vaccine against pre-erythrocytic malaria. SCIENTIFIC REPORTS, 7 (1), https://doi.org/10.1038/s41598-017-07246-0. | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://hdl.handle.net/11343/253528 | |
dc.description.abstract | The majority of routinely given vaccines require two or three immunisations for full protective efficacy. Single dose vaccination has long been considered a key solution to improving the global immunisation coverage. Recent infectious disease outbreaks have further highlighted the need for vaccines that can achieve full efficacy after a single administration. Viral vectors are a potent immunisation platform, benefiting from intrinsic immuno-stimulatory features while retaining excellent safety profile through the use of non-replicating viruses. We investigated the scope for enhancing the protective efficacy of a single dose adenovirus-vectored malaria vaccine in a mouse model of malaria by co-administering it with vaccine adjuvants. Out of 11 adjuvants, only two, Abisco®-100 and CoVaccineHTTM, enhanced vaccine efficacy and sterile protection following malaria challenge. The CoVaccineHTTM adjuvanted vaccine induced significantly higher proportion of antigen specific central memory CD8+ cells, and both adjuvants resulted in increased proportion of CD8+ T cells expressing the CD107a degranulation marker in the absence of IFNγ, TNFα and IL2 production. Our results show that the efficacy of vaccines designed to induce protective T cell responses can be positively modulated with chemical adjuvants and open the possibility of achieving full protection with a single dose immunisation. | |
dc.language | English | |
dc.publisher | NATURE PUBLISHING GROUP | |
dc.title | Adjuvanting a viral vectored vaccine against pre-erythrocytic malaria | |
dc.type | Journal Article | |
dc.identifier.doi | 10.1038/s41598-017-07246-0 | |
melbourne.affiliation.department | Medical Biology (W.E.H.I.) | |
melbourne.source.title | Scientific Reports | |
melbourne.source.volume | 7 | |
melbourne.source.issue | 1 | |
dc.rights.license | CC BY | |
melbourne.elementsid | 1320743 | |
melbourne.contributor.author | Longley, Rhea | |
dc.identifier.eissn | 2045-2322 | |
melbourne.accessrights | Open Access | |