Show simple item record

dc.contributor.authorAlmeida, ACG
dc.contributor.authorKuehn, A
dc.contributor.authorCastro, AJM
dc.contributor.authorVitor-Silva, S
dc.contributor.authorFigueiredo, EFG
dc.contributor.authorBrasil, LW
dc.contributor.authorBrito, MAM
dc.contributor.authorSampaio, VS
dc.contributor.authorBassat, Q
dc.contributor.authorFelger, I
dc.contributor.authorTadei, WP
dc.contributor.authorMonteiro, WM
dc.contributor.authorMueller, I
dc.contributor.authorLacerda, MVG
dc.date.accessioned2020-12-10T00:37:52Z
dc.date.available2020-12-10T00:37:52Z
dc.date.issued2018-03-20
dc.identifierpii: 10.1186/s13071-018-2787-7
dc.identifier.citationAlmeida, A. C. G., Kuehn, A., Castro, A. J. M., Vitor-Silva, S., Figueiredo, E. F. G., Brasil, L. W., Brito, M. A. M., Sampaio, V. S., Bassat, Q., Felger, I., Tadei, W. P., Monteiro, W. M., Mueller, I. & Lacerda, M. V. G. (2018). High proportions of asymptomatic and submicroscopic Plasmodium vivax infections in a peri-urban area of low transmission in the Brazilian Amazon. PARASITES & VECTORS, 11 (1), https://doi.org/10.1186/s13071-018-2787-7.
dc.identifier.issn1756-3305
dc.identifier.urihttp://hdl.handle.net/11343/253532
dc.description.abstractBACKGROUND: Population-based studies conducted in Latin America have shown a high proportion of asymptomatic and submicroscopic malarial infections. Considering efforts aiming at regional elimination, it is important to investigate the role of this asymptomatic reservoir in malaria transmission in peri-urban areas. This study aimed to estimate the prevalence of Plasmodium spp. and gametocyte burden on symptomatic and asymptomatic infections in the Brazilian Amazon. RESULTS: Two cross-sectional household surveys (CS) were conducted including all inhabitants in a peri-urban area of Manaus, western Amazonas State, Brazil. Malaria parasites were detected by light microscopy (LM) and qPCR. Sexual stages of Plasmodium spp. were detected by LM and RT-qPCR. A total of 4083 participants were enrolled during the two surveys. In CS1, the prevalence of Plasmodium vivax infections was 4.3% (86/2010) by qPCR and 1.6% (32/2010) by LM. Fifty percent (43/86) of P. vivax infected individuals (qPCR) carried P. vivax gametocytes. In CS2, 3.4% (70/2073) of participants had qPCR-detectable P. vivax infections, of which 42.9% (30/70) of infections were gametocyte positive. The P. vivax parasite density was associated with gametocyte carriage (P < 0.001). Sixty-seven percent of P. vivax infected individuals and 53.4% of P. vivax gametocyte carriers were asymptomatic. CONCLUSIONS: This study confirms a substantial proportion of asymptomatic and submicroscopic P. vivax infections in the study area. Most asymptomatic individuals carried gametocytes and presented low asexual parasitemia. This reservoir actively contributes to malaria transmission in the Brazilian Amazon, underscoring a need to implement more efficient control and elimination strategies.
dc.languageEnglish
dc.publisherBIOMED CENTRAL LTD
dc.titleHigh proportions of asymptomatic and submicroscopic Plasmodium vivax infections in a peri-urban area of low transmission in the Brazilian Amazon
dc.typeJournal Article
dc.identifier.doi10.1186/s13071-018-2787-7
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titleParasites and Vectors
melbourne.source.volume11
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1320796
melbourne.contributor.authorMueller, Ivo
dc.identifier.eissn1756-3305
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record